Post-stroke depression and lesion location: a systematic review

doi:10.1007/s00415-014-7534-1

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	Post-stroke depression and lesion location: a systematic review
	Wei, Na 1; Yong, Wu2 ; Li, Xinyan 1; Zhou, Yafan 1; Deng, Manfei 1; Zhu, Houze 1; Jin, Huijuan 1; Huijuan Jin
心理所单位排序	2
摘要	Post-stroke depression (PSD) is a frequent problem in stroke rehabilitation. Several studies have evaluated association between the lesion location and the risk of depression. Different conclusions and contradictory findings have been published. The aim of the present study was to perform a systematic meta-analysis to evaluate the relationship between PSD and lesion location. We researched PubMed, ISI Web of Science, EMBASE, and systematically reviewed available publications reporting investigations on stroke location and risk of PSD. Subgroup analyses were performed according to the time since stroke onset to assessment for PSD or the source of patients. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used for pooled analyses. Heterogeneity was assessed with Cochran’s Q test and I 2 test. Begg’s funnel plot and Egger’s test were used to examine the publication bias. A total of 43 studies involving 5,507 patients suffering from stroke were included in this meta-analysis. The pooled OR with 95 % CI for the overall association of stroke location and depression risk was 0.99 (0.88-1.11). Subgroups analyses highlighted that only studies with subacute post-stroke group (1-6 months) showed a statistical association between right hemisphere stroke and risk of depression (OR = 0.79, 95 % CI 0.66-0.93). This systematic review offered no support for the hypothesis that lesion of the left hemisphere was associated with an increased risk of depression after stroke. We only find significant association between right hemisphere stroke and incidence of depression for studies within subacute post-stroke phase.; Post-stroke depression (PSD) is a frequent problem in stroke rehabilitation. Several studies have evaluated association between the lesion location and the risk of depression. Different conclusions and contradictory findings have been published. The aim of the present study was to perform a systematic meta-analysis to evaluate the relationship between PSD and lesion location. We researched PubMed, ISI Web of Science, EMBASE, and systematically reviewed available publications reporting investigations on stroke location and risk of PSD. Subgroup analyses were performed according to the time since stroke onset to assessment for PSD or the source of patients. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used for pooled analyses. Heterogeneity was assessed with Cochran's Q test and I (2) test. Begg's funnel plot and Egger's test were used to examine the publication bias. A total of 43 studies involving 5,507 patients suffering from stroke were included in this meta-analysis. The pooled OR with 95 % CI for the overall association of stroke location and depression risk was 0.99 (0.88-1.11). Subgroups analyses highlighted that only studies with subacute post-stroke group (1-6 months) showed a statistical association between right hemisphere stroke and risk of depression (OR = 0.79, 95 % CI 0.66-0.93). This systematic review offered no support for the hypothesis that lesion of the left hemisphere was associated with an increased risk of depression after stroke. We only find significant association between right hemisphere stroke and incidence of depression for studies within subacute post-stroke phase.
关键词	Post-stroke depression Lesion location Meta-analysis
学科领域	变态心理学
	2015
语种	英语
DOI	10.1007/s00415-014-7534-1
发表期刊	JOURNAL OF NEUROLOGY
ISSN	0340-5354
卷号	262 期号:1 页码:81-90
期刊论文类型	Review
URL	查看原文
收录类别	SCI
资助项目	National Natural Science Foundation of China（81301165 ） ; Natural Science Fund of Hubei Province （2012FFB03706 ） ; China Postdoctoral Science Foundation （2014M552047 ）
WOS记录号	WOS:000348216000010
资助机构	National Natural Science Foundation of China ; Natural Science Fund of Hubei Province ; China Postdoctoral Science Foundation
引用统计	被引频次：130[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10203
专题	管理支撑系统
通讯作者	Huijuan Jin
作者单位	1.Huazhong Univ Sci & Technol, Inst Brain Res, Wuhan 430030, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Beijing 100015, Peoples R China
推荐引用方式 GB/T 7714	Wei, Na,Yong, Wu,Li, Xinyan,et al. Post-stroke depression and lesion location: a systematic review[J]. JOURNAL OF NEUROLOGY,2015,262(1):81-90.
APA	Wei, Na.,Yong, Wu.,Li, Xinyan.,Zhou, Yafan.,Deng, Manfei.,...&Huijuan Jin.(2015).Post-stroke depression and lesion location: a systematic review.JOURNAL OF NEUROLOGY,262(1),81-90.
MLA	Wei, Na,et al."Post-stroke depression and lesion location: a systematic review".JOURNAL OF NEUROLOGY 262.1(2015):81-90.

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