Ten-a Affects Fusion of Central Complex Primordia in Drosophila

	Ten-a Affects Fusion of Central Complex Primordia in Drosophila
	Cheng, Xuebo 1,2; Jiang, Huoqing 1; Li, Weizhe 1; Lv, Hailong 1; Gong, Zhefeng 1,3; Liu, Li1,4
摘要	The central complex of Drosophila melanogaster plays important functions in various behaviors, such as visual and olfactory memory, visual orientation, sleep, and movement control. However little is known about the genes regulating the development of the central complex. Here we report that a mutant gene affecting central complex morphology, cbd (central brain defect), was mapped to ten-a, a type II trans-membrane protein coding gene. Down-regulation of ten-a in pan-neural cells contributed to abnormal morphology of central complex. Over-expression of ten-a by C767-Gal4 was able to partially restore the abnormal central complex morphology in the cbd mutant. Tracking the development of FB primordia revealed that C767-Gal4 labeled interhemispheric junction that separated fan-shaped body precursors at larval stage withdrew to allow the fusion of the precursors. While the C767-Gal4 labeled structure did not withdraw properly and detached from FB primordia, the two fan-shaped body precursors failed to fuse in the cbd mutant. We propose that the withdrawal of C767-Gal4 labeled structure is related to the formation of the fan-shaped body. Our result revealed the function of ten-a in central brain development, and possible cellular mechanism underlying Drosophila fan-shaped body formation.
	2013-02-20
语种	英语
发表期刊	PLOS ONE
卷号	8 期号:2 页码:1-11
期刊论文类型	Article
收录类别	SCI
WOS关键词	INTRACELLULAR DOMAIN ; LOCOMOTOR BEHAVIOR ; SYNAPSE FORMATION ; GLIAL-CELLS ; BRAIN ; MELANOGASTER ; MEMORY ; BODY ; ORGANIZATION ; ARCHITECTURE
WOS标题词	Science & Technology
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000315184200221
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10701
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100080, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Zhejiang Univ, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China 4.Chinese Acad Sci, Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Cheng, Xuebo,Jiang, Huoqing,Li, Weizhe,et al. Ten-a Affects Fusion of Central Complex Primordia in Drosophila[J]. PLOS ONE,2013,8(2):1-11.
APA	Cheng, Xuebo,Jiang, Huoqing,Li, Weizhe,Lv, Hailong,Gong, Zhefeng,&Liu, Li.(2013).Ten-a Affects Fusion of Central Complex Primordia in Drosophila.PLOS ONE,8(2),1-11.
MLA	Cheng, Xuebo,et al."Ten-a Affects Fusion of Central Complex Primordia in Drosophila".PLOS ONE 8.2(2013):1-11.

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