Maternal Separation Induces Alterations in Reversal Learning and Brain-Derived Neurotrophic Factor Expression in Adult Rats

	Maternal Separation Induces Alterations in Reversal Learning and Brain-Derived Neurotrophic Factor Expression in Adult Rats
	Xue, Xiaofang 1; Shao, Shuang 1; Wang, Weiwen2 ; Shao, Feng 1; Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
心理所单位排序	2
摘要	Aims: Early postnatal maternal and/or sibling separation (MS) can play an important role in the development of psychopathologies during ontogeny. The purpose of the present study is to investigate the effects of repeated MS on the cognitive and brain-derived neurotrophic factor (BDNF) function of rats. Methods: We investigated the effects of repeated MS that lasted 3 h/day during postnatal days 1-21 on spatial learning and reversal learning in Morris water maze tests in male rats. The rats were tested in 4 trials. Moreover, we examined the effects of MS on BDNF protein expression in the medial prefrontal cortex (mPFC), the nucleus accumbens, and the hippocampus via immunohistochemistry measurements. Results: We found that repeated MS modestly disrupted reversal learning performance in the Morris water maze and decreased BDNF protein expression in the mPFC. Conclusion: The present study enhances our understanding of the neurobiological and behavioral consequences of repeated episodes of MS in rats to some degree. (C) 2013 S. Karger AG, Basel
关键词	Maternal and sibling separation Reversal learning Brain-derived neurotrophic factor Medial prefrontal cortex
学科领域	Physiological Psychology/biological Psychology,Developmental Psychology
	2013
语种	英语
发表期刊	NEUROPSYCHOBIOLOGY
ISSN	0302-282X
卷号	68 期号:4 页码:243-249
期刊论文类型	期刊论文
收录类别	SCI
项目简介	This work was supported by the National Natural Science Foundation of China (grant No. 31070910 and 91132728), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8), and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS关键词	SPRAGUE-DAWLEY RATS ; PREFRONTAL CORTEX ; SOCIAL-ISOLATION ; COGNITIVE FLEXIBILITY ; PREPULSE INHIBITION ; NUCLEUS-ACCUMBENS ; ISOLATION STRESS ; SCHIZOPHRENIA ; DEPRIVATION ; BDNF
WOS标题词	Science & Technology ; Social Sciences ; Life Sciences & Biomedicine
WOS研究方向	Neurosciences & Neurology ; Psychiatry ; Psychology
WOS类目	Neurosciences ; Psychiatry ; Psychology
WOS记录号	WOS:000328311900008
资助机构	National Natural Science Foundation of China [31070910, 91132728] ; Knowledge Innovation Program of the Chinese Academy of Sciences [KSCX2-EW-J-8] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10736
专题	中国科学院心理健康重点实验室
通讯作者	Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
作者单位	1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Xue, Xiaofang,Shao, Shuang,Wang, Weiwen,et al. Maternal Separation Induces Alterations in Reversal Learning and Brain-Derived Neurotrophic Factor Expression in Adult Rats[J]. NEUROPSYCHOBIOLOGY,2013,68(4):243-249.
APA	Xue, Xiaofang,Shao, Shuang,Wang, Weiwen,Shao, Feng,&Shao, F .(2013).Maternal Separation Induces Alterations in Reversal Learning and Brain-Derived Neurotrophic Factor Expression in Adult Rats.NEUROPSYCHOBIOLOGY,68(4),243-249.
MLA	Xue, Xiaofang,et al."Maternal Separation Induces Alterations in Reversal Learning and Brain-Derived Neurotrophic Factor Expression in Adult Rats".NEUROPSYCHOBIOLOGY 68.4(2013):243-249.

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