The Role of Interoception and Insular Cortex in Addiction

	The Role of Interoception and Insular Cortex in Addiction
	Li Chun-Lu1,2 ; Zhu Ning 1; Li Yong-Hui1 ; Meng Xiao-Lu1,2 ; Gao Jun1,2 ; Sui Nan1
摘要	Interoception is the sense of the physiological condition of the body. Recent studies suggested that interoception is involved in drug addiction and insular cortex is a key anatomical position. The neural mechanisms underlying such phenomena attract growing attention. In an effort to develop working hypotheses for future investigation, the article first reviewed the evidence of interoceptive regulation of addiction, and subsequently presented human and animal data that suggest a central role of the insular cortex in mediating interoception and addiction. On this basis, we proposed potential neurobiological mechanisms through which insular cortex may mediate drug addiction. Further, possible functional roles of neurotransmitters in the insular cortex are discussed in the context of drug addiction.
关键词	interoception insular cortex addiction
	2013
语种	英语
发表期刊	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
卷号	40 期号:1 页码:15-21
期刊论文类型	Article
收录类别	SCI
WOS关键词	TAKING DECISION-MAKING ; FUNCTIONAL CONNECTIVITY ; NUCLEUS-ACCUMBENS ; VISCERAL CORTEX ; DRUG-ADDICTION ; RAT ; ACTIVATION ; BRAIN ; RISK ; STOP
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000314003100002
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10804
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Li Chun-Lu,Zhu Ning,Li Yong-Hui,et al. The Role of Interoception and Insular Cortex in Addiction[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2013,40(1):15-21.
APA	Li Chun-Lu,Zhu Ning,Li Yong-Hui,Meng Xiao-Lu,Gao Jun,&Sui Nan.(2013).The Role of Interoception and Insular Cortex in Addiction.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,40(1),15-21.
MLA	Li Chun-Lu,et al."The Role of Interoception and Insular Cortex in Addiction".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 40.1(2013):15-21.