Meta-Analysis Indicates That the European GWAS-Identified Risk SNP rs1344706 within ZNF804A Is Not Associated with Schizophrenia in Han Chinese Population

	Meta-Analysis Indicates That the European GWAS-Identified Risk SNP rs1344706 within ZNF804A Is Not Associated with Schizophrenia in Han Chinese Population
	Li, Ming 1,5; Zhang, Hui 1; Luo, Xiong-jian 2; Gao, Lei 3,5; Qi, Xue-bin 1; Gourraud, Pierre-Antoine 4; Su, Bing 1; Su, B (reprint author), Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Yunnan, Peoples R China.
心理所单位排序	3
摘要	Recent genetic association studies have implicated several candidate susceptibility variants for schizophrenia among general populations. Rs1344706, an intronic SNP within ZNF804A, was identified as one of the most compelling candidate risk SNPs for schizophrenia in Europeans through genome-wide association studies (GWASs) and replications as well as large-scale meta-analyses. However, in Han Chinese, the results for rs1344706 are inconsistent, and whether rs1344706 is an authentic risk SNP for schizophrenia in Han Chinese is inconclusive. Here, we conducted a systematic meta-analysis of rs1344706 with schizophrenia in Chinese population by combining all available case-control samples (N = 12), including a total of 8,982 cases and 12,342 controls. The results of our meta-analysis were not able to confirm an association of rs1344706 A-allele with schizophrenia (p = 0.10, odds ratio = 1.06, 95% confidence interval = 0.99-1.13). Such absence of association was further confirmed by the non-superiority test (p = 0.0003), suggesting that rs1344706 is not a risk SNP for schizophrenia in Han Chinese. Detailed examinations of individual samples revealed potential sampling bias in previous replication studies in Han Chinese. The absence of rs1344706 association in Han Chinese suggest a potential genetic heterogeneity in the susceptibility of schizophrenia on this locus and also demonstrate the difficulties in replicating genome-wide association findings of schizophrenia across different ethnic populations.
学科领域	Abnormal Psychology
	2013
语种	英语
发表期刊	PLOS ONE
ISSN	1932-6203
卷号	8 期号:6
期刊论文类型	期刊论文
URL	查看原文
收录类别	SCI
项目简介	This work was supported by grants from the National 973 project of China (grant numbers, 2011CBA00401) and the National Natural Science Foundation of China (U1202225, 31130051 and 31071101). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
WOS关键词	GENOME-WIDE ASSOCIATION ; COMMON VARIANTS ; SUSCEPTIBILITY ; GENE ; BIAS
WOS标题词	Science & Technology
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000320322400055
资助机构	National 973 project of China [2011CBA00401] ; National Natural Science Foundation of China [U1202225, 31130051, 31071101]
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10810
专题	中国科学院心理健康重点实验室
通讯作者	Su, B (reprint author), Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Yunnan, Peoples R China.
作者单位	1.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Yunnan, Peoples R China 2.Univ Rochester, Flaum Eye Inst, Rochester, NY USA 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.Univ Calif San Francisco, Sch Med, Dept Neurol, San Francisco, CA USA 5.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, Ming,Zhang, Hui,Luo, Xiong-jian,et al. Meta-Analysis Indicates That the European GWAS-Identified Risk SNP rs1344706 within ZNF804A Is Not Associated with Schizophrenia in Han Chinese Population[J]. PLOS ONE,2013,8(6).
APA	Li, Ming.,Zhang, Hui.,Luo, Xiong-jian.,Gao, Lei.,Qi, Xue-bin.,...&Su, B .(2013).Meta-Analysis Indicates That the European GWAS-Identified Risk SNP rs1344706 within ZNF804A Is Not Associated with Schizophrenia in Han Chinese Population.PLOS ONE,8(6).
MLA	Li, Ming,et al."Meta-Analysis Indicates That the European GWAS-Identified Risk SNP rs1344706 within ZNF804A Is Not Associated with Schizophrenia in Han Chinese Population".PLOS ONE 8.6(2013).

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