A follow-up fMRI study of a transferable placebo anxiolytic effect

	A follow-up fMRI study of a transferable placebo anxiolytic effect
	Zhang, Wencai1 ; Qin, Shaozheng 3; Guo, Jianyou1 ; Luo, Jing1,2 ; Luo, J
心理所单位排序	1
摘要	Our previous study showed that placebo expectations can develop in a transferable manner; for example, a placebo expectation developed within an analgesic experience may lead to reduced anxiety. Considering that activities in such emotion-responsive areas as the amygdala and insula can be detected through functional magnetic resonance imaging (fMRI), we used fMRI to further study the transferable placebo anxiolytic effect. A main-effect analysis showed that activity in the amygdala and insula was reduced in the placebo condition, whereas an interaction analysis showed activity in the two regions was selectively attenuated in the placebo condition when unpleasant pictures were viewed. We also observed greater activity in the subgenual anterior cingulate cortex under placebo conditions when either emotionally negative or neutral pictures were viewed. These data suggest that the anxiety-relieving placebo effect arose from a reward-related response underpinned by the participants' expectations.
关键词	Placebo anxiolytic effect Expectation Negative emotion Amygdala Subgenual anterior cingulate cortex Functional magnetic resonance imaging (fMRI)
学科领域	健康心理学
	2011-08-01
语种	英语
发表期刊	PSYCHOPHYSIOLOGY
ISSN	0048-5772
卷号	48 期号:8 页码:1119-1128
期刊论文类型	Article
URL	查看原文
收录类别	SCI ; SSCI
项目简介	This research was supported by the National Basic Research Program of China (Grant 2010CB833904), the National Natural Science Foundation of China (Grants 30970890 and 30770708), the National Hi-Tech Research and Development Program of China (Grants 2008AA022604 and 2009BAI77B06), the Young Scientists Fund of the Institute of Psychology (Grant Y0CX451S01), and the Knowledge Innovation Program of the Chinese Academy of Sciences (Grant KSCX2-EW-J-8).
WOS记录号	WOS:000292449900010
资助机构	National Basic Research Program of China [2010CB833904] ; National Natural Science Foundation of China [30970890, 30770708] ; National Hi-Tech Research and Development Program of China [2008AA022604, 2009BAI77B06] ; Institute of Psychology [Y0CX451S01] ; Chinese Academy of Sciences [KSCX2-EW-J-8]
引用统计	被引频次：25[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10851
专题	中国科学院心理健康重点实验室
通讯作者	Luo, J
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Capital Normal Univ, Learning & Cognit Lab, Beijing, Peoples R China 3.Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Ctr Cognit Neuroimaging, NL-6525 ED Nijmegen, Netherlands
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Zhang, Wencai,Qin, Shaozheng,Guo, Jianyou,et al. A follow-up fMRI study of a transferable placebo anxiolytic effect[J]. PSYCHOPHYSIOLOGY,2011,48(8):1119-1128.
APA	Zhang, Wencai,Qin, Shaozheng,Guo, Jianyou,Luo, Jing,&Luo, J.(2011).A follow-up fMRI study of a transferable placebo anxiolytic effect.PSYCHOPHYSIOLOGY,48(8),1119-1128.
MLA	Zhang, Wencai,et al."A follow-up fMRI study of a transferable placebo anxiolytic effect".PSYCHOPHYSIOLOGY 48.8(2011):1119-1128.

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