Abnormal spontaneous brain activity in medication-naive ADHD children: A resting state fMRI study

	Abnormal spontaneous brain activity in medication-naive ADHD children: A resting state fMRI study
	Yang, Hong 2; Wu, Qi-Zhu 1; Guo, Lan-Ting 3; Li, Qian-Qian 3; Long, Xiang-Yu 4; Huang, Xiao-Qi 1; Chan, Raymond C. K.5 ; Gong, Qi-Yong 1; Gong, QY (reprint author), Sichuan Univ, W China Hosp, Ctr Med Imaging, Dept Radiol,HMRRC, Chengdu 610041, Sichuan, Peoples R China.
心理所单位排序	5
摘要	Abnormal baseline brain functional connectivity in attention-deficit/hyperactivity disorder (ADHD) has been revealed in a number of studies by using resting-state functional MRI (rfMRI). The aim of this study was to investigate the spontaneous frontal activities in medication-nave ADHD boys using the rfMRI derived index, amplitude of low-frequency fluctuation (ALFF). In total 17 ADHD boys and 17 matched controls were recruited to undergo rfMRI scan on a 3.0 T MRI system. For each subject, six oblique slices covering the frontal areas were acquired with a rapid sampling rate (TR = 400 ms). Functional images were processed in AFNI for calculation of ALFF and then group comparison was performed using voxel-based t-test. With a corrected threshold of p < 0.05 determined by AlphaSim, we found that in comparison with controls, ADHD patients demonstrated higher ALFF values in the left superior frontal gyrus and sensorimotor cortex (SMC), and lower ALFF values in the bilateral anterior, middle cingulate and the right middle frontal gyrus (MFG). Significant correlations were found between patients' WSCT measures and the peak ALFF located in the right MFG (r = 0.69, p = 0.02), and the left SMC (r = 0.65, p = 0.03). Our results revealed abnormal frontal activities at resting state associated with underlying physiopathology of ADHD, and suggested the ALFF analysis to be a potential approach in further exploration of this disorder. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
关键词	Attention-deficit/hyperactivity disorder Resting-state fMRI Spontaneous brain activity
学科领域	Developmental Psychology，physiological Psychology/biological Psychology
	2011-09-15
语种	英语
发表期刊	NEUROSCIENCE LETTERS
ISSN	0304-3940
卷号	502 期号:2 页码:89-93
期刊论文类型	Article
URL	查看原文
收录类别	SCI
项目简介	This study was supported by the National Natural Science Foundation of China (Nos. 81030027, 30900362 and 30971043), National Basic Research Program (973 No. 2007CB512305/2). The funding sponsors have not been involved in the design, execution of the study, in the manuscript drafting and in the decision to submit the paper for publication.
WOS记录号	WOS:000295314100005
资助机构	National Natural Science Foundation of China [81030027, 30900362, 30971043] ; National Basic Research Program (973) [2007CB512305/2]
引用统计	被引频次：62[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10861
专题	中国科学院心理健康重点实验室
通讯作者	Gong, QY (reprint author), Sichuan Univ, W China Hosp, Ctr Med Imaging, Dept Radiol,HMRRC, Chengdu 610041, Sichuan, Peoples R China.
作者单位	1.Sichuan Univ, W China Hosp, Ctr Diagnost Imaging, Dept Radiol,HMRRC, Chengdu 610041, Sichuan, Peoples R China 2.Zhejiang Univ, Affiliated Hosp 1, Coll Med Sci, Dept Radiol, Hangzhou 310003, Zhejiang, Peoples R China 3.Sichuan Univ, W China Hosp, Dept Psychiat, Chengdu 610041, Sichuan, Peoples R China 4.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Yang, Hong,Wu, Qi-Zhu,Guo, Lan-Ting,et al. Abnormal spontaneous brain activity in medication-naive ADHD children: A resting state fMRI study[J]. NEUROSCIENCE LETTERS,2011,502(2):89-93.
APA	Yang, Hong.,Wu, Qi-Zhu.,Guo, Lan-Ting.,Li, Qian-Qian.,Long, Xiang-Yu.,...&Gong, QY .(2011).Abnormal spontaneous brain activity in medication-naive ADHD children: A resting state fMRI study.NEUROSCIENCE LETTERS,502(2),89-93.
MLA	Yang, Hong,et al."Abnormal spontaneous brain activity in medication-naive ADHD children: A resting state fMRI study".NEUROSCIENCE LETTERS 502.2(2011):89-93.

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