Cigarette Smoking and Cognitive Function in Chinese Male Schizophrenia: A Case-Control study

	Cigarette Smoking and Cognitive Function in Chinese Male Schizophrenia: A Case-Control study
	Zhang, Xiang Yang 1,2,3; Chen, Da Chun 3; Xiu, Mei Hong 3; Haile, Colin N.2; Sun, Hongqiang 3,4; Lu, Lin 4; Kosten, Therese A.2; Kosten, Thomas R.2,3; Zhang, XY (reprint author), Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China.
心理所单位排序	1
摘要	Schizophrenic patients have higher smoking rates than the general population. Studies show that smoking may be a form of self-medication in an attempt to alleviate cognitive deficits in schizophrenic patients of European background. This study examined the relationships between smoking and cognitive deficits in Chinese schizophrenic patients, which have previously received little systemic study. We recruited 580 male chronic patients meeting DSM-IV criteria for schizophrenia and 175 male control subjects who were matched on age and education. The subjects completed a detailed cigarette smoking questionnaire, the Fagerstrom Test for Nicotine Dependence (FTND), and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Patients also were rated on the Positive and Negative Symptom Scale (PANSS), the Simpson and Angus Extrapyramidal Symptom Rating Scale (SAES), and the Abnormal Involuntary Movement Scale (AIMS). All five RBANS subscales except for the Visuospatial/Constructional index showed significantly lower cognitive performance for schizophrenics than normal controls. The schizophrenic smokers scored lower than the schizophrenic nonsmokers on the RBANS total score and the Visuospatial/Constructional and Immediate Memory indices. Similarly, the control smokers scored lower than the control non-smokers on the RBANS total score and the Immediate Memory index. Also, the schizophrenic smokers consistently performed the poorest on the cognitive domains of the RBANS. Among the schizophrenic patients, smokers displayed significantly fewer negative symptoms than non-smokers. Using multivariate regression analysis the following variables were independently associated with the RBANS total score: years of education, PANSS negative symptom score, age at schizophrenia onset, and number of hospitalizations. Our results show that smoking is associated with significant cognitive impairment in both schizophrenic patients and normal controls, but the smokers with schizophrenia had a reduced level of negative symptoms, suggesting that the benefits of smoking for those with schizophrenia may be limited to certain aspects of a given clinical phenotype.
学科领域	Abnormal Psychology
	2012-05-03
语种	英语
发表期刊	PLOS ONE
ISSN	1932-6203
卷号	7 期号:5
期刊论文类型	Article
URL	查看原文
收录类别	SCI
项目简介	This study was funded by the Stanley Medical Research Institute (03T-459 and 05T-726), and the Department of Veterans Affairs, VISN 16, Mental Illness Research, Education and Clinical Center (MIRECC), U.S. National Institute of Health K05-DA0454, P50-DA18827 and U01-MH79639. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
WOS记录号	WOS:000305343400042
资助机构	Stanley Medical Research Institute [03T-459, 05T-726] ; Department of Veterans Affairs, VISN 16, Mental Illness Research, Education and Clinical Center (MIRECC), U.S. National Institute of Health [K05-DA0454, P50-DA18827, U01-MH79639]
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/11439
专题	中国科学院心理健康重点实验室
通讯作者	Zhang, XY (reprint author), Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 2.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA 3.Peking Univ, Beijing HuiLongGuan Hosp, Beijing 100871, Peoples R China 4.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
第一作者单位	中国科学院心理研究所
推荐引用方式 GB/T 7714	Zhang, Xiang Yang,Chen, Da Chun,Xiu, Mei Hong,et al. Cigarette Smoking and Cognitive Function in Chinese Male Schizophrenia: A Case-Control study[J]. PLOS ONE,2012,7(5).
APA	Zhang, Xiang Yang.,Chen, Da Chun.,Xiu, Mei Hong.,Haile, Colin N..,Sun, Hongqiang.,...&Zhang, XY .(2012).Cigarette Smoking and Cognitive Function in Chinese Male Schizophrenia: A Case-Control study.PLOS ONE,7(5).
MLA	Zhang, Xiang Yang,et al."Cigarette Smoking and Cognitive Function in Chinese Male Schizophrenia: A Case-Control study".PLOS ONE 7.5(2012).

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