Early fear as a predictor of avoidance in a rat model of post-traumatic stress disorder

	Early fear as a predictor of avoidance in a rat model of post-traumatic stress disorder
	Chen, Xiaoyu 1; Li, Yonghui5 ; Li, Sa 1; Kirouac, Gilbert J.1,2,3,4; Kirouac, GJ (reprint author), Univ Manitoba, Fac Dent, Dept Oral Biol, 780 Bannatyne Ave, Winnipeg, MB R3E 0W2, Canada.
心理所单位排序	2
摘要	Exposure of humans and animals to an intensely fearful experience can lead to an enduring behavioral profile involving fear and avoidance. The present study examined if rats that show more fear to a novel tone one day after exposure to footshocks exhibit more avoidance-like responses over a 4-week period. Rats were exposed to an episode of moderately intense footshock (5 x 2s episodes of 1.5 mA presented randomly over 3 min). Shock rats that exhibited a high level of fear (HR) to a novel tone one day after the shock exposure showed more avoidance of open spaces and novel rats when compared to shock rats that exhibited a lower level of fear to the novel tone (LR). Similarly, HR emitted more ultrasonic vocalization in the dysphoric range (20-30 kHz) when placed in a novel chamber or the chamber in which shock was given. This study highlights the importance of early fear as a contributing factor for the development of lasting changes in avoidance. These results also support the view that the presence of an intense peritraumatic stress response may be a predictor of the subsequent development of a lasting negative emotional state in humans exposed to trauma. (C) 2011 Elsevier B.V. All rights reserved.
关键词	Post-traumatic stress disorder Fear Avoidance Footshock Rat Stress
学科领域	Physiological Psychology/biological Psychology
	2012
语种	英语
发表期刊	BEHAVIOURAL BRAIN RESEARCH
ISSN	0166-4328
卷号	226 期号:1 页码:112-117
期刊论文类型	Article
URL	查看原文
收录类别	SCI
项目简介	The study was supported by Canadian Institutes of Health Research (CIHR; MOP68909 to G.J.K.). The authors declare that except for income received from their primary employer, no financial support has been received from any individual or corporate entity.
WOS记录号	WOS:000296941400014
资助机构	Canadian Institutes of Health Research (CIHR) [MOP68909]
引用统计	被引频次：38[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/11479
专题	中国科学院心理健康重点实验室
通讯作者	Kirouac, GJ (reprint author), Univ Manitoba, Fac Dent, Dept Oral Biol, 780 Bannatyne Ave, Winnipeg, MB R3E 0W2, Canada.
作者单位	1.Univ Manitoba, Fac Dent, Dept Oral Biol, Winnipeg, MB R3E 0W2, Canada 2.Univ Manitoba, Fac Dent, Dept Psychiat, Winnipeg, MB R3E 0W2, Canada 3.Univ Manitoba, Fac Med, Dept Oral Biol, Winnipeg, MB R3E 0W2, Canada 4.Univ Manitoba, Fac Med, Dept Psychiat, Winnipeg, MB R3E 0W2, Canada 5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Chen, Xiaoyu,Li, Yonghui,Li, Sa,et al. Early fear as a predictor of avoidance in a rat model of post-traumatic stress disorder[J]. BEHAVIOURAL BRAIN RESEARCH,2012,226(1):112-117.
APA	Chen, Xiaoyu,Li, Yonghui,Li, Sa,Kirouac, Gilbert J.,&Kirouac, GJ .(2012).Early fear as a predictor of avoidance in a rat model of post-traumatic stress disorder.BEHAVIOURAL BRAIN RESEARCH,226(1),112-117.
MLA	Chen, Xiaoyu,et al."Early fear as a predictor of avoidance in a rat model of post-traumatic stress disorder".BEHAVIOURAL BRAIN RESEARCH 226.1(2012):112-117.

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