Inhibition of the Acquisition of Conditioned Place Aversion by Dopaminergic Lesions of the Central Nucleus of the Amygdala in Morphine-Treated Rats

	Inhibition of the Acquisition of Conditioned Place Aversion by Dopaminergic Lesions of the Central Nucleus of the Amygdala in Morphine-Treated Rats
	Xu, W.1,2; Li, Y. H.1; Tan, B. P.1; Luo, X. J.1; Xiao, L.1; Zheng, X. G.1; Yang, X. Y.1; Sui, N.1; Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Mental Hlth Key Lab, POB 1603, Beijing 100101, Peoples R China.
心理所单位排序	1
摘要	The negative affective state of opiate abstinence plays an important role in craving and relapse to compulsive drug use. The dopamine system participates in the reward effects of opiate use and the aversive effect of opiate abstinence. The amygdala is an essential neural substrate for associative learning of emotion. To establish a model of conditioned place aversion (CPA) in morphine-treated rats, we used different visual and tactual cues as conditioned stimuli (CS) within a conditioning apparatus. An injection of naloxone served as the unconditioned stimulus (US). The 6-hydroxydopamine (6-OHDA) lesion technique was used to investigate the effects of the dopaminergic system of the central nucleus of the amygdala (CeA) on naloxone-induced CPA. Rats were rendered physically dependent via administration of increasing doses of morphine delivered via intraperitoneal injection. Doses increased by 20% each day for 14 days, starting from an initial dose of 6 mg/kg. All rats also received a low dose of naloxone (0.1 mg/kg) by injection 4 hours after morphine treatment on days 11 and 13 to induce CPA in a biased two-compartment conditioned place apparatus. Morphine-dependent rats with sham lesions were found to develop significant CPA after naloxone treatment. Bilateral 6-OHDA lesions of the CeA impaired the acquisition of CPA but had no effect on locomotor activity. These results suggest that the dopaminergic system of the CeA plays an important role in the negative affective state of opiate abstinence.
关键词	Conditioned place aversion Central nucleus of amygdala Dopamine 6-OHDA
学科领域	Medical Psychology
	2012
语种	英语
发表期刊	PHYSIOLOGICAL RESEARCH
ISSN	0862-8408
卷号	61 期号:4 页码:437-442
期刊论文类型	Article
URL	查看原文
收录类别	SCI
项目简介	This work was supported by the National Basic Research Program (2009CB522002), the Chinese Academy of Sciences (KSCX2-EW-R-12, KSCX2-EW-Q-18), and the National Natural Science Foundation (31070911)
WOS记录号	WOS:000309194600013
资助机构	National Basic Research Program [2009CB522002] ; Chinese Academy of Sciences [KSCX2-EW-R-12, KSCX2-EW-Q-18] ; National Natural Science Foundation [31070911]
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/11865
专题	中国科学院心理健康重点实验室
通讯作者	Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Mental Hlth Key Lab, POB 1603, Beijing 100101, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Psychol, Mental Hlth Key Lab, Beijing 100101, Peoples R China 2.Beijing Univ Chem Technol, Sch Humanities & Law, Mental Hlth Educ Res Ctr, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Xu, W.,Li, Y. H.,Tan, B. P.,et al. Inhibition of the Acquisition of Conditioned Place Aversion by Dopaminergic Lesions of the Central Nucleus of the Amygdala in Morphine-Treated Rats[J]. PHYSIOLOGICAL RESEARCH,2012,61(4):437-442.
APA	Xu, W..,Li, Y. H..,Tan, B. P..,Luo, X. J..,Xiao, L..,...&Sui, N .(2012).Inhibition of the Acquisition of Conditioned Place Aversion by Dopaminergic Lesions of the Central Nucleus of the Amygdala in Morphine-Treated Rats.PHYSIOLOGICAL RESEARCH,61(4),437-442.
MLA	Xu, W.,et al."Inhibition of the Acquisition of Conditioned Place Aversion by Dopaminergic Lesions of the Central Nucleus of the Amygdala in Morphine-Treated Rats".PHYSIOLOGICAL RESEARCH 61.4(2012):437-442.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
WOS_000309194600013.（761KB）			限制开放	Apache License	请求全文