Haptoglobin 2-2 Genotype Is Associated with Increased Risk of Type 2 Diabetes Mellitus in Northern Chinese

	Haptoglobin 2-2 Genotype Is Associated with Increased Risk of Type 2 Diabetes Mellitus in Northern Chinese
	Shi, Xiaohong 1; Sun, Liang 1; Wang, Li 2; Jin, Feng3 ; Sun, Junfeng 1; Zhu, Xiaoquan 1; Tang, Lei 1; Qu, Yanchun 4; Yang, Ze 1; Yang, Z (reprint author), Minist Hlth, Beijing Hosp, Inst Geriatr, Key Lab Geriatr, Beijing 100730, Peoples R China.
心理所单位排序	3
摘要	The aim of this study was to investigate the association between haptoglobin (Hp) gene polymorphism and occurrence of type 2 diabetes mellitus (T2DM) in a northern Chinese population. We studied the association of the Hp gene polymorphism with T2DM in 584 unrelated T2DM patients and 690 control subjects with normal glucose tolerance among northern Chinese. The patients were diagnosed in accordance with the guidelines of the American Diabetes Association. The clinical characteristics of the study population were recorded, and the Hp genotype was determined. The frequencies of the genotypes in the group of T2DM patients and the controls were as follows: Hp2-2, 51.7% and 44.1%; Hp2-1, 39.7% and 45.1%; and Hp1-1, 8.6% and 10.9%, respectively. There was significant difference for the genotypic and allelic distribution between the two groups (p = 0.021 and p = 0.007, respectively). Even after readjusting for the confounding effects of age, gender, and body mass index, a significant effect of genotypes on T2DM was still found in the recessive model for the Hp2 allele tested (p = 0.002). Those who had the Hp2-2 genotype had a significantly higher risk for T2DM than those with other genotypes (odds ratio = 1.441, 95% confidence interval = 1.143-1.817). The results showed that the Hp2-2 genotype is associated with increased risk of T2DM in the northern Chinese Han population.
学科领域	Medical Psychology
	2012-06-01
语种	英语
发表期刊	GENETIC TESTING AND MOLECULAR BIOMARKERS
ISSN	1945-0265
卷号	16 期号:6 页码:563-568
期刊论文类型	Article
URL	查看原文
收录类别	SCI
项目简介	This research was supported by the grants from the Major State Basic Research Development Program of China (973 Program) (No. 2006CB503901) and the National Natural Science Foundation of China (No. 81061120527; No. 30801208).
WOS记录号	WOS:000305633000019
资助机构	Major State Basic Research Development Program of China (973 Program) [2006CB503901] ; National Natural Science Foundation of China [81061120527, 30801208]
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/12836
专题	中国科学院心理健康重点实验室
通讯作者	Yang, Z (reprint author), Minist Hlth, Beijing Hosp, Inst Geriatr, Key Lab Geriatr, Beijing 100730, Peoples R China.
作者单位	1.Minist Hlth, Beijing Hosp, Inst Geriatr, Key Lab Geriatr, Beijing 100730, Peoples R China 2.Chinese Acad Sci, Inst Genet & Dev Biol, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.Tianjin Med Univ, Hosp 2, Tianjin Inst Urol, Tianjin, Peoples R China
推荐引用方式 GB/T 7714	Shi, Xiaohong,Sun, Liang,Wang, Li,et al. Haptoglobin 2-2 Genotype Is Associated with Increased Risk of Type 2 Diabetes Mellitus in Northern Chinese[J]. GENETIC TESTING AND MOLECULAR BIOMARKERS,2012,16(6):563-568.
APA	Shi, Xiaohong.,Sun, Liang.,Wang, Li.,Jin, Feng.,Sun, Junfeng.,...&Yang, Z .(2012).Haptoglobin 2-2 Genotype Is Associated with Increased Risk of Type 2 Diabetes Mellitus in Northern Chinese.GENETIC TESTING AND MOLECULAR BIOMARKERS,16(6),563-568.
MLA	Shi, Xiaohong,et al."Haptoglobin 2-2 Genotype Is Associated with Increased Risk of Type 2 Diabetes Mellitus in Northern Chinese".GENETIC TESTING AND MOLECULAR BIOMARKERS 16.6(2012):563-568.

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