PERSONALIZED TREATMENT OF ADULT DEPRESSION: MEDICATION, PSYCHOTHERAPY, OR BOTH? A SYSTEMATIC REVIEW

	PERSONALIZED TREATMENT OF ADULT DEPRESSION: MEDICATION, PSYCHOTHERAPY, OR BOTH? A SYSTEMATIC REVIEW
	Cuijpers, Pim 1,2; Reynolds, Charles F., III 3; Donker, Tara 1,2; Li, Juan4 ; Andersson, Gerhard 5,6; Beekman, Aartjan 7; Cuijpers, P (reprint author), Vrije Univ Amsterdam, Dept Clin Psychol, Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.
心理所单位排序	4
摘要	Background Personalized medicine aims to identify which characteristics of an individual predict the outcome of a specific treatment, in order to get a better match between the individual and the treatment received. We conducted a systematic review and meta-analysis of randomized trials comparing two treatments directly in a group of patients with a specific characteristic. Methods We searched relevant studies from bibliographical databases and included trials comparing (1) medication with psychotherapy, (2) medication with combined treatment, and (3) psychotherapy with combined treatment, in specific target groups (a) with a predefined sociodemographic characteristic, (b) a specific type of depression, (c) a comorbid mental or somatic disorder, or (d) from a specific setting (outpatients, primary care). Results We included 52 studies with 4,734 depressed patients. In these studies, 20 characteristics of the target groups were examined. The results showed that medication is probably the best treatment for dysthymia, and combined treatments are more effective in depressed outpatients, as well as in depressed older adults. However, in order to examine the 20 characteristics in the three categories of comparisons, 254 studies would be needed for having sufficient statistical power to show an effect size of g = 0.5. Currently, only 20.1% of these studies have been conducted. Conclusions Although a considerable number of studies have compared medication, psychotherapy, and combined treatments, and some preliminary results are useful for deciding which treatment is best for which patient, the development of personalized treatment of depression has only just begun.
关键词	antidepressants clinical trials depression dysthymic disorder treatment
学科领域	Personality Psychology,Cognitive Neuroscience
	2012-10-01
语种	英语
发表期刊	DEPRESSION AND ANXIETY
ISSN	1091-4269
卷号	29 期号:10 页码:855-864
期刊论文类型	Article
URL	查看原文
收录类别	SSCI
WOS记录号	WOS:000309394600004
引用统计	被引频次：105[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/12893
专题	中国科学院心理健康重点实验室
通讯作者	Cuijpers, P (reprint author), Vrije Univ Amsterdam, Dept Clin Psychol, Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.
作者单位	1.Vrije Univ Amsterdam, Dept Clin Psychol, NL-1081 BT Amsterdam, Netherlands 2.Vrije Univ Amsterdam, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands 3.Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA 4.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China 5.Linkoping Univ, Swedish Inst Disabil Res, Dept Behav Sci & Learning, S-58183 Linkoping, Sweden 6.Karolinska Inst, Psychiat Sect, Dept Clin Neurosci, Stockholm, Sweden 7.Vrije Univ Amsterdam, Med Ctr Amsterdam, Dept Psychiat, Amsterdam, Netherlands
推荐引用方式 GB/T 7714	Cuijpers, Pim,Reynolds, Charles F., III,Donker, Tara,et al. PERSONALIZED TREATMENT OF ADULT DEPRESSION: MEDICATION, PSYCHOTHERAPY, OR BOTH? A SYSTEMATIC REVIEW[J]. DEPRESSION AND ANXIETY,2012,29(10):855-864.
APA	Cuijpers, Pim.,Reynolds, Charles F., III.,Donker, Tara.,Li, Juan.,Andersson, Gerhard.,...&Cuijpers, P .(2012).PERSONALIZED TREATMENT OF ADULT DEPRESSION: MEDICATION, PSYCHOTHERAPY, OR BOTH? A SYSTEMATIC REVIEW.DEPRESSION AND ANXIETY,29(10),855-864.
MLA	Cuijpers, Pim,et al."PERSONALIZED TREATMENT OF ADULT DEPRESSION: MEDICATION, PSYCHOTHERAPY, OR BOTH? A SYSTEMATIC REVIEW".DEPRESSION AND ANXIETY 29.10(2012):855-864.

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