Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources

	Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources
	Chang, Suhua1,2 ; Zhang, Weina1,2 ; Gao, Lei 1,2; Wang, Jing1 ; Wang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
心理所单位排序	1
摘要	Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable psychiatric disorder characterized by hyperactivity, inattention and increased im-pulsivity. In recent years, a large number of genetic studies for ADHD have been published and related genetic data has been accumulated dramatically. To provide researchers a comprehensive ADHD genetic resource, we previously developed the first genetic database for ADHD (ADHDgene). The abundant genetic data provides novel candidates for further study. Meanwhile, it also brings new challenge for selecting promising candidate genes for replication and verification research. In this study, we surveyed the computational tools for candidate gene prioritization and selected five tools, which integrate multiple data sources for gene prioritization, to prioritize ADHD candidate genes in ADHDgene. The prioritization analysis resulted in 16 prioritized candidate genes, which are mainly involved in several major neurotransmitter systems or in nervous system development pathways. Among these genes, nervous system development related genes, especially SNAP25, STX1A and the gene-gene interactions related with each of them deserve further investigations. Our results may provide new insight for further verification study and facilitate the exploration of pathogenesis mechanism of ADHD.
关键词	gene prioritization attention deficit hyperactivity disorder candidate genes multiple data sources
学科领域	Cognitive Psychology
	2012-07-01
语种	英语
发表期刊	PROTEIN & CELL
ISSN	1674-800X
卷号	3 期号:7 页码:526-534
期刊论文类型	Article
收录类别	SCI
项目简介	This work was supported by Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS记录号	WOS:000310531200007
资助机构	Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
引用统计	被引频次：10[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/12902
专题	中国科学院心理健康重点实验室
通讯作者	Wang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Chang, Suhua,Zhang, Weina,Gao, Lei,et al. Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources[J]. PROTEIN & CELL,2012,3(7):526-534.
APA	Chang, Suhua,Zhang, Weina,Gao, Lei,Wang, Jing,&Wang, J .(2012).Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources.PROTEIN & CELL,3(7),526-534.
MLA	Chang, Suhua,et al."Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources".PROTEIN & CELL 3.7(2012):526-534.

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