Neurobiological Changes of Schizotypy: Evidence From Both Volume-Based Morphometric Analysis and Resting-State Functional Connectivity

	Neurobiological Changes of Schizotypy: Evidence From Both Volume-Based Morphometric Analysis and Resting-State Functional Connectivity
	Wang, Yi1 ; Yan, Chao2 ; Yin, Da-zhi 3; Fan, Ming-xia 3; Cheung, Eric F. C.4; Pantelis, Christos 5,6; Chan, Raymond C. K.1,7
摘要	The current study sought to examine the underlying brain changes in individuals with high schizotypy by integrating networks derived from brain structural and functional imaging. Individuals with high schizotypy (n = 35) and low schizotypy (n = 34) controls were screened using the Schizotypal Personality Questionnaire and underwent brain structural and resting-state functional magnetic resonance imaging on a 3T scanner. Voxel-based morphometric analysis and graph theory-based functional network analysis were conducted. Individuals with high schizotypy showed reduced gray matter (GM) density in the insula and the dorsolateral prefrontal gyrus. The graph theoretical analysis showed that individuals with high schizotypy showed similar global properties in their functional networks as low schizotypy individuals. Several hubs of the functional network were identified in both groups, including the insula, the lingual gyrus, the postcentral gyrus, and the rolandic operculum. More hubs in the frontal lobe and fewer hubs in the occipital lobe were identified in individuals with high schizotypy. By comparing the functional connectivity between clusters with abnormal GM density and the whole brain, individuals with high schizotypy showed weaker functional connectivity between the left insula and the putamen, but stronger connectivity between the cerebellum and the medial frontal gyrus. Taken together, our findings suggest that individuals with high schizotypy present changes in terms of GM and resting-state functional connectivity, especially in the frontal lobe.
关键词	schizotypy voxel-based morphometry graph theory functional connectivity insula
	2015-03-01
语种	英语
发表期刊	SCHIZOPHRENIA BULLETIN
ISSN	0586-7614
卷号	41 期号:2 页码:S444-S454
期刊论文类型	Article
收录类别	SSCI
WOS记录号	WOS:000353548800010
引用统计	被引频次：50[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/13528
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China 2.E China Normal Univ, Sch Psychol & Cognit Sci, Shanghai Key Lab Brain Funct Genom MOE & STCSM, Shanghai 200062, Peoples R China 3.E China Normal Univ, Shanghai Key Lab MRI, Shanghai 200062, Peoples R China 4.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 5.Univ Melbourne, Dept Psychiat, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia 6.Melbourne Hlth, Melbourne, Vic, Australia 7.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Ctr, Beijing 100101, Peoples R China
第一作者单位	认知与发展心理学研究室
推荐引用方式 GB/T 7714	Wang, Yi,Yan, Chao,Yin, Da-zhi,et al. Neurobiological Changes of Schizotypy: Evidence From Both Volume-Based Morphometric Analysis and Resting-State Functional Connectivity[J]. SCHIZOPHRENIA BULLETIN,2015,41(2):S444-S454.
APA	Wang, Yi.,Yan, Chao.,Yin, Da-zhi.,Fan, Ming-xia.,Cheung, Eric F. C..,...&Chan, Raymond C. K..(2015).Neurobiological Changes of Schizotypy: Evidence From Both Volume-Based Morphometric Analysis and Resting-State Functional Connectivity.SCHIZOPHRENIA BULLETIN,41(2),S444-S454.
MLA	Wang, Yi,et al."Neurobiological Changes of Schizotypy: Evidence From Both Volume-Based Morphometric Analysis and Resting-State Functional Connectivity".SCHIZOPHRENIA BULLETIN 41.2(2015):S444-S454.

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