Increased serum S100B in never-medicated and medicated schizophrenic patients

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	Increased serum S100B in never-medicated and medicated schizophrenic patients
	Zhang, Xiang Yang 1,2,3; Xiu, Mei Hong 2; Song, Cai 4; Chen, Da Chun 2; Wu, Gui Ying 3; Haile, Colin N.3; Kosten, Therese A.3; Kosten, Thomas R.3
摘要	S100B is a calcium-binding protein, which is produced primarily by glial cells. It modulates the proliferation and differentiation of neurons and glia by affecting protective and apoptotic mechanisms. Recently, several studies have shown increased serum S100B levels in patients with schizophrenia, suggesting that S100B might be relevant to the pathophysiology of schizophrenia. S100B levels were assessed using ELISA in the serum of 80 never-medicated early-stage and 82 medicated chronic schizophrenia patients and 97 healthy controls subjects. The psychopathology of schizophrenia was assessed by the Positive and Negative Syndrome Scale (PANSS). Our results showed significantly increased serum 51008 levels in both never-medicated and medicated patients compared to normal controls (both p < 0.0001). S100B in never-medicated patients was also markedly increased, compared with medicated patients (p < 0.0001). S100B changes observed were irrespective of neuroleptic medication. gender, age, and smoking. Increased S100B levels in the early stage of schizophrenia suggest that glial cell activation or structural damage may be part of a neurodegenerative process in schizophrenia. The lower S100B levels in chronic than early-stage patients further suggest that antipsychotic treatment may reduce this neurodegeneration. (C) 2010 Elsevier Ltd. All rights reserved.
关键词	Schizophrenia S100B Early psychosis Antipsychotic treatment Psychopathology
	2010-12-01
语种	英语
发表期刊	JOURNAL OF PSYCHIATRIC RESEARCH
ISSN	0022-3956
卷号	44 期号:16 页码:1236-1240
期刊论文类型	Article
收录类别	SCI ; SSCI
WOS记录号	WOS:000285952000016
引用统计	被引频次：33[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/13673
专题	中国科学院心理研究所回溯数据库(1956-2010)
作者单位	1.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 2.Beijing Hui Long Guan Hosp, Ctr Biol Psychiat, Beijing, Peoples R China 3.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA 4.Univ Prince Edward Isl, Atlantic Vet Coll, Dept Biomed Sci, Charlottetown, PE C1A 4P3, Canada
第一作者单位	中国科学院心理研究所
推荐引用方式 GB/T 7714	Zhang, Xiang Yang,Xiu, Mei Hong,Song, Cai,et al. Increased serum S100B in never-medicated and medicated schizophrenic patients[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2010,44(16):1236-1240.
APA	Zhang, Xiang Yang.,Xiu, Mei Hong.,Song, Cai.,Chen, Da Chun.,Wu, Gui Ying.,...&Kosten, Thomas R..(2010).Increased serum S100B in never-medicated and medicated schizophrenic patients.JOURNAL OF PSYCHIATRIC RESEARCH,44(16),1236-1240.
MLA	Zhang, Xiang Yang,et al."Increased serum S100B in never-medicated and medicated schizophrenic patients".JOURNAL OF PSYCHIATRIC RESEARCH 44.16(2010):1236-1240.