High-Frequency Stimulation of the Subthalamic Nucleus Restores Neural and Behavioral Functions During Reaction Time Task in a Rat Model of Parkinson's Disease

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	High-Frequency Stimulation of the Subthalamic Nucleus Restores Neural and Behavioral Functions During Reaction Time Task in a Rat Model of Parkinson's Disease
	Li, Xiang-Hong 2; Wang, Jin-Yan1 ; Gao, Ge1 ; Chang, Jing-Yu 3; Woodward, Donald J.3; Luo, Fei1,2 ; Fei Luo
通讯作者邮箱	[email protected]
心理所单位排序	1
摘要	Deep brain stimulation (DBS) has been used in the clinic to treat Parkinson's disease (PD) and other neuropsychiatric disorders. Our previous work has shown that DBS in the subthalamic nucleus (STN) can improve major motor deficits, and induce a variety of neural responses in rats with unilateral dopamine (DA) lesions. In the present study, we examined the effect of STN DBS on reaction time (RT) performance and parallel changes in neural activity in the cortico-basal ganglia regions of partially bilateral DA- lesioned rats. We recorded neural activity with a multiple-channel single-unit electrode system in the primary motor cortex (MI), the STN, and the substantia nigra pars reticulata (SNr) during RT test. RT performance was severely impaired following bilateral injection of 6-OHDA into the dorsolateral part of the striatum. In parallel with such behavioral impairments, the number of responsive neurons to different behavioral events was remarkably decreased after DA lesion. Bilateral STN DBS improved RT performance in 6-OHDA lesioned rats, and restored operational behavior-related neural responses in cortico-basal ganglia regions. These behavioral and electrophysiological effects of DBS lasted nearly an hour after DBS termination. These results demonstrate that a partial DA lesion-induced impairment of RT performance is associated with changes in neural activity in the cortico-basal ganglia circuit. Furthermore, STN DBS can reverse changes in behavior and neural activity caused by partial DA depletion. The observed long-lasting beneficial effect of STN DBS suggests the involvement of the mechanism of neural plasticity in modulating corticobasal ganglia circuits. (C) 2009 Wiley-Liss, Inc.
关键词	deep brain stimulation electrophysiology striatum motor cortex single-unit recording
学科领域	生理心理学/生物心理学
	2010-05-15
语种	英语
发表期刊	JOURNAL OF NEUROSCIENCE RESEARCH
ISSN	0360-4012
卷号	88 期号:7 页码:1510-1521
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000276858600011
引用统计	被引频次：25[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/13692
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Fei Luo
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 2.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China 3.Neurosci Res Inst N Carolina, Winston Salem, NC USA
推荐引用方式 GB/T 7714	Li, Xiang-Hong,Wang, Jin-Yan,Gao, Ge,et al. High-Frequency Stimulation of the Subthalamic Nucleus Restores Neural and Behavioral Functions During Reaction Time Task in a Rat Model of Parkinson's Disease[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2010,88(7):1510-1521.
APA	Li, Xiang-Hong.,Wang, Jin-Yan.,Gao, Ge.,Chang, Jing-Yu.,Woodward, Donald J..,...&Fei Luo.(2010).High-Frequency Stimulation of the Subthalamic Nucleus Restores Neural and Behavioral Functions During Reaction Time Task in a Rat Model of Parkinson's Disease.JOURNAL OF NEUROSCIENCE RESEARCH,88(7),1510-1521.
MLA	Li, Xiang-Hong,et al."High-Frequency Stimulation of the Subthalamic Nucleus Restores Neural and Behavioral Functions During Reaction Time Task in a Rat Model of Parkinson's Disease".JOURNAL OF NEUROSCIENCE RESEARCH 88.7(2010):1510-1521.

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