| Neural mechanisms of oxytocin receptor gene mediating anxiety-related temperament | |
Wang, Junping1; Qin, Wen1; Liu, Bing2; Zhou, Yuan3 ; Wang, Dawei1; Zhang, Yunting1; Jiang, Tianzi2; Yu, Chunshui1,4
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| 摘要 | A common variant (rs53576) of the OXTR gene has been implicated in a number of socio-emotional phenotypes, such as anxiety-related behavior. Previous studies have demonstrated that A-allele carriers have higher levels of physiological and dispositional stress reactivity and depressive symptomatology compared to those with the GG genotype, but the mediating neural mechanisms remain poorly understood. We combined voxel-based morphometry and resting-state functional connectivity analyses in a large cohort of healthy young Chinese Han individuals to test the hypothesis that the OXTR gene polymorphism influences an anxiety-related temperamental trait, as assessed by the harm avoidance subscale from the Tridimensional Personality Questionnaire via modulating the gray matter volume and resting-state functional connectivity of the brain, especially the limbic system. We revealed that female subjects with the AA genotype showed increased harm avoidance scores relative to G-carrier females. We also found that, compared to female individuals with the GG/GA genotype, female individuals with the AA genotype exhibited significantly smaller amygdala volumes bilaterally (especially the centromedial subregion), with a trend of allele-load-dependence. Compared to female individuals with the GG/GA genotype, female subjects with the AA genotype demonstrated reduced resting-state functional coupling between the prefrontal cortex and amygdala bilaterally, also with an allele-load-dependent trend. Furthermore, the magnitude of prefrontal-amygdala coupling in the left hemisphere was positively correlated with harm avoidance scores in female subjects. Our findings highlight a possible neural pathway by which a naturally occurring variation of the OXTR gene may affect an anxiety-related temperamental trait in female subjects by modulating prefrontal-amygdala functional connectivity. |
| 关键词 | Amygdala Anxiety Imaging Genetics Oxytocin Receptor Single Nucleotide Polymorphism |
| 2014-09-01 | |
| 语种 | 英语 |
| 发表期刊 | BRAIN STRUCTURE & FUNCTION
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| ISSN | 1863-2653 |
| 卷号 | 219期号:5页码:1543-1554 |
| 期刊论文类型 | Article |
| 收录类别 | SCI |
| WOS记录号 | WOS:000341375500003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/13722 |
| 专题 | 社会与工程心理学研究室 |
| 作者单位 | 1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 2.Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Ctr Social & Econ Behav, Beijing, Peoples R China 4.Tianjin Med Univ, Sch Med Imaging, Tianjin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Junping,Qin, Wen,Liu, Bing,et al. Neural mechanisms of oxytocin receptor gene mediating anxiety-related temperament[J]. BRAIN STRUCTURE & FUNCTION,2014,219(5):1543-1554. |
| APA | Wang, Junping.,Qin, Wen.,Liu, Bing.,Zhou, Yuan.,Wang, Dawei.,...&Yu, Chunshui.(2014).Neural mechanisms of oxytocin receptor gene mediating anxiety-related temperament.BRAIN STRUCTURE & FUNCTION,219(5),1543-1554. |
| MLA | Wang, Junping,et al."Neural mechanisms of oxytocin receptor gene mediating anxiety-related temperament".BRAIN STRUCTURE & FUNCTION 219.5(2014):1543-1554. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| WOS_000341375500003.（2293KB） | 期刊论文 | 出版稿 | 暂不开放 | CC BY-NC-SA | 请求全文 | |
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