Disrupted cortical network as a vulnerability marker for obsessive-compulsive disorder

	Disrupted cortical network as a vulnerability marker for obsessive-compulsive disorder
	Peng, Ziwen 1,2; Shi, Feng 1; Shi, Changzheng 3; Yang, Qiong 4; Chan, Raymond C. K.5 ; Shen, Dinggang 1,6
摘要	Morphological alterations of brain structure are generally assumed to be involved in the pathophysiology of obsessive-compulsive disorder (OCD). Yet, little is known about the morphological connectivity properties of structural brain networks in OCD or about the heritability of those morphological connectivity properties. To better understand these properties, we conducted a study that defined three different groups: OCD group with 30 subjects, siblings group with 19 subjects, and matched controls group with 30 subjects. A structural brain network was constructed using 68 cortical regions of each subject within their respective group (i.e., one brain network for each group). Both small-worldness and modularity were measured to reflect the morphological connectivity properties of each constructed structural brain network. When compared to the matched controls, the structural brain networks of patients with OCD indeed exhibited atypical small-worldness and modularity. Specifically, small-worldness showed decreased local efficiency, and modularity showed reduced intra-connectivity in Module III (default mode network) and increased interconnectivity between Module I (executive function) and Module II (cognitive control/spatial). Intriguingly, the structured brain networks of the unaffected siblings showed similar small-worldness and modularity as OCD patients. Based on the atypical structural brain networks observed in OCD patients and their unaffected siblings, abnormal small-worldness and modularity may indicate a candidate endophenotype for OCD.
关键词	Obsessive-compulsive Disorder Cortical Thickness Brain Networks Modularity Small-worldness
	2014-09-01
语种	英语
发表期刊	BRAIN STRUCTURE & FUNCTION
ISSN	1863-2653
卷号	219 期号:5 页码:1801-1812
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000341375500021
引用统计	被引频次：20[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14107
专题	中国科学院心理健康重点实验室
作者单位	1.Univ N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA 2.S China Normal Univ, Dept Psychol, Guangzhou, Guangdong, Peoples R China 3.Jinan Univ, Affiliated Hosp 1, Med Imaging Ctr, Guangzhou, Guangdong, Peoples R China 4.Guangzhou Psychiat Hosp, Guangzhou, Guangdong, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 6.Korea Univ, Dept Brain & Cognit Engn, Seoul, South Korea
推荐引用方式 GB/T 7714	Peng, Ziwen,Shi, Feng,Shi, Changzheng,et al. Disrupted cortical network as a vulnerability marker for obsessive-compulsive disorder[J]. BRAIN STRUCTURE & FUNCTION,2014,219(5):1801-1812.
APA	Peng, Ziwen,Shi, Feng,Shi, Changzheng,Yang, Qiong,Chan, Raymond C. K.,&Shen, Dinggang.(2014).Disrupted cortical network as a vulnerability marker for obsessive-compulsive disorder.BRAIN STRUCTURE & FUNCTION,219(5),1801-1812.
MLA	Peng, Ziwen,et al."Disrupted cortical network as a vulnerability marker for obsessive-compulsive disorder".BRAIN STRUCTURE & FUNCTION 219.5(2014):1801-1812.

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