Genetic and Environmental Etiologies of Adolescent Dysfunctional Attitudes: A Twin Study

	Genetic and Environmental Etiologies of Adolescent Dysfunctional Attitudes: A Twin Study
	Chen, Jie; Li, Xinying
摘要	Despite the importance of dysfunctional attitudes in the development and maintenance of depression, little is known about the etiological origin of dysfunctional attitudes. The Dysfunctional Attitudes Scale for Children was administered to 674 adolescent twins derived from the Beijing Twin Study (BeTwiSt). Four hundred and thirty-nine monozygotic and 235 same-gender dizygotic twin pairs were included. Approximately 54% were females. The age range of the twins was 11-17 years. Model-fitting analyses were conducted. Biometric genetic model-fitting estimates indicated that additive genetic factors accounted for 31% (95% CI: 11%, 45%) of variance in adolescent dysfunctional attitude. The influence of shared environmental factors was small and negligible (9% [95% CI: 0%, 27%]). Non-shared environmental factors explained 60% (95% CI: 55%, 66%) of variance. Equating the estimate parameters across gender or age groups resulted in a non-significant difference of model fit, but there were trends suggesting higher heritability in females and older adolescents. Our results provide evidence for moderate heritability of dysfunctional attitudes in adolescents. Dysfunctional attitudes can be used as an endophenotype to identify risk genes for depression.
关键词	dysfunctional attitudes genetic and environmental influences twin study
	2014-02-01
语种	英语
发表期刊	TWIN RESEARCH AND HUMAN GENETICS
ISSN	1832-4274
卷号	17 期号:1 页码:16-22
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000331900800003
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14152
专题	中国科学院心理健康重点实验室
作者单位	Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Chen, Jie,Li, Xinying. Genetic and Environmental Etiologies of Adolescent Dysfunctional Attitudes: A Twin Study[J]. TWIN RESEARCH AND HUMAN GENETICS,2014,17(1):16-22.
APA	Chen, Jie,&Li, Xinying.(2014).Genetic and Environmental Etiologies of Adolescent Dysfunctional Attitudes: A Twin Study.TWIN RESEARCH AND HUMAN GENETICS,17(1),16-22.
MLA	Chen, Jie,et al."Genetic and Environmental Etiologies of Adolescent Dysfunctional Attitudes: A Twin Study".TWIN RESEARCH AND HUMAN GENETICS 17.1(2014):16-22.

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