rSNPBase: a database for curated regulatory SNPs

	rSNPBase: a database for curated regulatory SNPs
	Guo, Liyuan1 ; Du, Yang 1,2; Chang, Suhua1 ; Zhang, Kunlin1 ; Wang, Jing1
摘要	In recent years, human regulatory SNPs (rSNPs) have been widely studied. Here, we present database rSNPBase, freely available at http://rsnp.psych.ac.cn/, to provide curated rSNPs that analyses the regulatory features of all SNPs in the human genome with reference to experimentally supported regulatory elements. In contrast with previous SNP functional annotation databases, rSNPBase is characterized by several unique features. (i) To improve reliability, all SNPs in rSNPBase are annotated with reference to experimentally supported regulatory elements. (ii) rSNPBase focuses on rSNPs involved in a wide range of regulation types, including proximal and distal transcriptional regulation and post-transcriptional regulation, and identifies their potentially regulated genes. (iii) Linkage disequilibrium (LD) correlations between SNPs were analysed so that the regulatory feature is annotated to SNP-set rather than a single SNP. (iv) rSNPBase provides the spatio-temporal labels and experimental eQTL labels for SNPs. In summary, rSNPBase provides more reliable, comprehensive and user-friendly regulatory annotations on rSNPs and will assist researchers in selecting candidate SNPs for further genetic studies and in exploring causal SNPs for in-depth molecular mechanisms of complex phenotypes.
	2014
语种	英语
发表期刊	NUCLEIC ACIDS RESEARCH
ISSN	0305-1048
卷号	42 期号:D1 页码:D1033-D1039
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000331139800152
引用统计	被引频次：92[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14192
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Guo, Liyuan,Du, Yang,Chang, Suhua,et al. rSNPBase: a database for curated regulatory SNPs[J]. NUCLEIC ACIDS RESEARCH,2014,42(D1):D1033-D1039.
APA	Guo, Liyuan,Du, Yang,Chang, Suhua,Zhang, Kunlin,&Wang, Jing.(2014).rSNPBase: a database for curated regulatory SNPs.NUCLEIC ACIDS RESEARCH,42(D1),D1033-D1039.
MLA	Guo, Liyuan,et al."rSNPBase: a database for curated regulatory SNPs".NUCLEIC ACIDS RESEARCH 42.D1(2014):D1033-D1039.

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