Molecular genetic studies of ADHD and its candidate genes: A review

	Molecular genetic studies of ADHD and its candidate genes: A review
	Li, Zhao1,2 ; Chang, Su-hua1 ; Zhang, Liu-yan1,2 ; Gao, Lei 1,2; Wang, Jing1
摘要	Attention-deficit/hyperactivity disorder (ADHD) is a common childhood-onset psychiatric disorder with high heritability. In recent years, numerous molecular genetic studies have been published to investigate susceptibility loci for ADHD. These results brought valuable candidates for further research, but they also presented great challenge for profound understanding of genetic data and general patterns of current molecular genetic studies of ADHD since they are scattered and heterogeneous. In this review, we presented a retrospective review of more than 300 molecular genetic studies for ADHD from two aspects: (1) the main achievements of various studies were summarized, including linkage studies, candidate-gene association studies, genome-wide association studies and genome-wide copy number variation studies, with a special focus on general patterns of study design and common sample features; (2) candidate genes for ADHD have been systematically evaluated in three ways for better utilization. The thorough summary of the achievements from various studies will provide an overview of the research status of molecular genetics studies for ADHD. Meanwhile, the analysis of general patterns and sample characteristics on the basis of these studies, as well as the integrative review of candidate ADHD genes, will propose new clues and directions for future experiment design. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
关键词	Attention-deficit/hyperactivity Disorder Linkage Study Association Study Study Design Sample Characteristics
	2014-09-30
语种	英语
发表期刊	PSYCHIATRY RESEARCH
ISSN	0165-1781
卷号	219 期号:1 页码:10-24
期刊论文类型	Review
收录类别	SSCI
WOS记录号	WOS:000339143700002
引用统计	被引频次：89[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14241
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Li, Zhao,Chang, Su-hua,Zhang, Liu-yan,et al. Molecular genetic studies of ADHD and its candidate genes: A review[J]. PSYCHIATRY RESEARCH,2014,219(1):10-24.
APA	Li, Zhao,Chang, Su-hua,Zhang, Liu-yan,Gao, Lei,&Wang, Jing.(2014).Molecular genetic studies of ADHD and its candidate genes: A review.PSYCHIATRY RESEARCH,219(1),10-24.
MLA	Li, Zhao,et al."Molecular genetic studies of ADHD and its candidate genes: A review".PSYCHIATRY RESEARCH 219.1(2014):10-24.

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