Hyperactivation of working memory-related brain circuits in newly diagnosed middle-aged type 2 diabetics

	Hyperactivation of working memory-related brain circuits in newly diagnosed middle-aged type 2 diabetics
	He, Xiao-Song 1,2; Wang, Zhao-Xin 1,3,4; Zhu, You-Zhi 5; Wang, Nan 6; Hu, Xiaoping 7,8; Zhang, Da-Ren 1; Zhu, De-Fa 6; Zhou, Jiang-Ning 1
摘要	Type 2 diabetes mellitus (T2DM) is well known for its adverse impacts on brain and cognition, which leads to multidimensional cognitive deficits and wildly spread cerebral structure abnormalities. However, existing literatures are mainly focused on patients with advanced age or extended T2DM duration. Therefore, it remains unclear whether and how brain function would be affected at the initial onset stage of T2DM in relatively younger population. In current study, twelve newly diagnosed middle-aged T2DM patients with no previous diabetic treatment history and twelve matched controls were recruited. Brain activations during a working memory task, the digit n-back paradigm (0-, 1- and 2-back), were obtained with functional magnetic resonance imaging and tested by repeated measures ANOVA. Whereas patients performed the n-back task comparably well as controls, significant load-by-group interactions of brain activation were found in the right dorsolateral prefrontal cortex (DLPFC), left middle/inferior frontal gyrus, and left parietal cortex, where patients exhibited hyperactivation in the 2-back, but not the 0-back or 1-back condition compared to controls. Furthermore, the severity of chronic hyperglycemia, estimated by glycosylated hemoglobin (HbA(1c)) level, was entered into partial correlational analyses with task-related brain activations, while controlling for the real-time influence of glucose, estimated by instant plasma glucose level measured before scanning. Significant positive correlations were found between HbA(1c) and brain activations in the anterior cingulate cortex and bilateral DLPFC only in patients. Taken together, these findings suggest there might be a compensatory mechanism due to brain inefficiency related to chronic hyperglycemia at the initial onset stage of T2DM.
关键词	Type 2 diabetes Chronic hyperglycemia Working memory Functional magnetic resonance imaging (fMRI)
	2015-02-01
语种	英语
发表期刊	ACTA DIABETOLOGICA
ISSN	0940-5429
卷号	52 期号:1 页码:133-142
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000349224100015
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14262
专题	中国科学院行为科学重点实验室
作者单位	1.Univ Sci & Technol China, Sch Life Sci, CAS Key Lab Brain Funct & Dis, Hefei 230027, Anhui, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 3.E China Normal Univ, Key Lab Brain Funct Genom MOE, Shanghai 200062, Peoples R China 4.E China Normal Univ, STCSM, Inst Cognit Neurosci, Sch Psychol & Cognit Sci, Shanghai 200062, Peoples R China 5.PLA 105 Hosp, Dept Radiol, Hefei, Anhui, Peoples R China 6.Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, Anhui Geriatr Inst, Hefei 230022, Anhui, Peoples R China 7.Georgia Tech, Dept Biomed Engn, Atlanta, GA USA 8.Emory Univ, Atlanta, GA 30322 USA
第一作者单位	中国科学院行为科学重点实验室
推荐引用方式 GB/T 7714	He, Xiao-Song,Wang, Zhao-Xin,Zhu, You-Zhi,et al. Hyperactivation of working memory-related brain circuits in newly diagnosed middle-aged type 2 diabetics[J]. ACTA DIABETOLOGICA,2015,52(1):133-142.
APA	He, Xiao-Song.,Wang, Zhao-Xin.,Zhu, You-Zhi.,Wang, Nan.,Hu, Xiaoping.,...&Zhou, Jiang-Ning.(2015).Hyperactivation of working memory-related brain circuits in newly diagnosed middle-aged type 2 diabetics.ACTA DIABETOLOGICA,52(1),133-142.
MLA	He, Xiao-Song,et al."Hyperactivation of working memory-related brain circuits in newly diagnosed middle-aged type 2 diabetics".ACTA DIABETOLOGICA 52.1(2015):133-142.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
WOS_000349224100015.（666KB）	期刊论文	出版稿	暂不开放	CC BY-NC-SA	请求全文