Anti-inflammation Effects of Cordyceps sinensis Mycelium in Focal Cerebral Ischemic Injury Rats

	Anti-inflammation Effects of Cordyceps sinensis Mycelium in Focal Cerebral Ischemic Injury Rats
	Liu, Zhenquan; Li, Pengtao; Zhao, Dan; Tang, Huiling; Guo, Jianyou; Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
心理所单位排序	2
摘要	Brain ischemia-reperfusion (IR) triggers a complex series of biochemical events including inflammation. To test the neuroprotective efficacy of Cordyceps sinensis mycelium (CSM) in a rat model of focal cerebral IR, ischemic animals were treated with CSM. They were evaluated at 24 h after reperfusion for neurological deficit score. Furthermore, the mechanism of the anti-inflammatory potential of CSM in the regulation of nuclear factor kappaB, polymorphonuclear cells (PMN), interleukin-1 beta (IL-1 beta), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha), adhesion molecule (ICAM-1), and cyclooxygenase-2 (COX-2) was determined by ELISA and immunohistochemistry. CSM significantly inhibited IR-induced up-regulation of NF-kappaB activation and the brain production of IL-1 beta, TNF-alpha, iNOS, ICAM-1, and COX-2. Moreover, CSM suppressed infiltration of PMN. The study demonstrates the neuroprotective potential of CSM inhibition through anti-inflammation in a rat model of ischemia-reperfusion.
关键词	CSM inflammation ischemia-reperfusion inflammatory cells inflammatory mediators
学科领域	Medical Psychology
	2011
语种	英语
发表期刊	INFLAMMATION
ISSN	0360-3997
卷号	34 期号:6 页码:639-644
期刊论文类型	期刊论文
URL	查看原文
收录类别	SCI
项目简介	This work was supported by the Key New Drugs Innovation project from Ministry of Science and Technology (2009ZX09502-017), the project from Key Laboratory of Mental Health, Chinese Academy of Sciences, Young Scientist project from IPCAS (08CX043004), NNSF grant (30800301), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254).
WOS记录号	WOS:000297198400016
资助机构	Ministry of Science and Technology [2009ZX09502-017] ; Key Laboratory of Mental Health, Chinese Academy of Sciences [08CX043004] ; NNSF [30800301] ; Chinese Academy of Sciences [KSCX2-YW-R-254]
引用统计	被引频次：41[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14293
专题	中国科学院心理健康重点实验室
通讯作者	Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
推荐引用方式 GB/T 7714	Liu, Zhenquan,Li, Pengtao,Zhao, Dan,et al. Anti-inflammation Effects of Cordyceps sinensis Mycelium in Focal Cerebral Ischemic Injury Rats[J]. INFLAMMATION,2011,34(6):639-644.
APA	Liu, Zhenquan,Li, Pengtao,Zhao, Dan,Tang, Huiling,Guo, Jianyou,&Guo, JY .(2011).Anti-inflammation Effects of Cordyceps sinensis Mycelium in Focal Cerebral Ischemic Injury Rats.INFLAMMATION,34(6),639-644.
MLA	Liu, Zhenquan,et al."Anti-inflammation Effects of Cordyceps sinensis Mycelium in Focal Cerebral Ischemic Injury Rats".INFLAMMATION 34.6(2011):639-644.

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