肠脑健康状况问卷的初步编制及信效度检验

	肠脑健康状况问卷的初步编制及信效度检验
其他题名	Antidepressive effects of petroleum ether extract from Ranae Oviductu and its possible mechanism
	段云峰; 吴晓丽; 金锋
通讯作者邮箱	[email protected]
心理所单位排序	2
摘要	目的编制一份测量肠脑健康状况的问卷并检验其信效度。方法经查阅文献和访谈形成含31项的预测问卷;分别对180名和479名被试进行项目分析和探索性因素分析以及信效度检验,选状态-特质焦虑问卷、自评抑郁量表和阿森斯失眠量表为效标。结果项目分析和探索性因素分析表明包含3个维度:肠道状态、饮食习惯和排便情况,21个项目的肠脑健康状况问卷,共解释了54.7%的变异;信度分析显示各维度信度系数在0.64~0.79之间,重测信度在0.70~0.78之间;效度分析表明各维度能反映总问卷所要测查的内容;各维度与总分间存在显著相关(r=0.488~0.798,P<0.01)。结论初步编制的肠脑健康状况问卷具有良好的信效度,可用于肠脑健康状况的相关研究。
其他摘要	Objective To study the antidepressive effect of the petroleum ether extract from Ranae Oviductus （PERO） on chronic mild stress depressive rat model and its mechanism. Methods The rats were divided into control, model, Fluoxetine （10 mg/kg, positive control）, and different doses （30, 100, and 300 mg/kg） of PERO groups. The rats in PERO groups were administered once daily for 21 d, while the rats in the control and model groups were administered with equivalent normal saline. After 1 h for the rats in PERO and model groups and 0.5 h for the rats in Fluoxetine group of the last administration, the chronic unpredictable mild stress for 21 d was used to induce the depression in rats. The body weight was measured and the depressive-like behaviors were evaluated by the open-field test and sucrose preference test. Then the corticosterone level in the rat plasma was detected by enzyme-linked immunosorbent assay （ELISA） and the brain-derived neurotrophic factor （BDNF） protein levels in the hippocampus were measured by Western blotting analysis. Results Compared with the control group, the body weight, sucrose preference, and motion distance in open-field test of rats were decreased, the corticosterone level in plasma was increased, and the BDNF level in hippocampus was decreased. Compared with the model group, PERO treatment alleviated the body weight decreasing, increased the sucrose preference and motion distance, reduced the corticosterone level in the plasma of rats, and increased the BDNF level in hippocampus of rats. Conclusion The antidepressive effect of PERO is likely mediated by modulating the fimction of hypothalamic-pituitary-adrenalaxis and increasing the expression of BDNF in brain tissues.
关键词	心理测量肠脑健康状况因素分析信效度心理评估
学科领域	心理测量
	2013
语种	中文
发表期刊	中国健康心理学杂志
ISSN	1005-1252
卷号	44 期号:12 页码:1823-1826
期刊论文类型	期刊论文
URL	查看原文
收录类别	CSCD
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14429
专题	中国科学院心理健康重点实验室
通讯作者	金锋
作者单位	中国科学院心理健康重点实验室
第一作者单位	中国科学院心理健康重点实验室
通讯作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	段云峰,吴晓丽,金锋. 肠脑健康状况问卷的初步编制及信效度检验[J]. 中国健康心理学杂志,2013,44(12):1823-1826.
APA	段云峰,吴晓丽,&金锋.(2013).肠脑健康状况问卷的初步编制及信效度检验.中国健康心理学杂志,44(12),1823-1826.
MLA	段云峰,et al."肠脑健康状况问卷的初步编制及信效度检验".中国健康心理学杂志 44.12(2013):1823-1826.

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