Network analysis reveals a stress-affected common gene module among seven stress-related diseases/systems which provides potential targets for mechanism research

	Network analysis reveals a stress-affected common gene module among seven stress-related diseases/systems which provides potential targets for mechanism research
	Guo, Liyuan1 ; Du, Yang 1,2; Wang, Jing1
摘要	Chronic stress (CS) was reported to associate with many complex diseases and stress-related diseases show strong comorbidity; however, molecular analyses have not been performed to date to evaluate common stress-induced biological processes across these diseases. We utilized networks constructed by genes from seven genetic databases of stress-related diseases or systems to explore the common mechanisms. Genes were connected based on the interaction information of proteins they encode. A common sub-network constructed by 561 overlapping genes and 8863 overlapping edges among seven networks was identified and it provides a common gene module among seven stress-related diseases/systems. This module is significantly overlapped with network that constructed by genes from the CS gene database. 36 genes with high connectivity (hub genes) were identified from seven networks as potential key genes in those diseases/systems, 33 of hub genes were included in the common module. Genes in the common module were enriched in 190 interactive gene ontology (GO) functional clusters which provide potential disease mechanism. In conclusion, by analyzing gene networks we revealed a stress-affected common gene module among seven stress-related diseases/systems which provides insight into the process of stress induction of disease and suggests potential gene and pathway candidates for further research.
	2015-08-06
语种	英语
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	5 期号:0 页码:12939
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000359127400001
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/15204
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Guo, Liyuan,Du, Yang,Wang, Jing. Network analysis reveals a stress-affected common gene module among seven stress-related diseases/systems which provides potential targets for mechanism research[J]. SCIENTIFIC REPORTS,2015,5(0):12939.
APA	Guo, Liyuan,Du, Yang,&Wang, Jing.(2015).Network analysis reveals a stress-affected common gene module among seven stress-related diseases/systems which provides potential targets for mechanism research.SCIENTIFIC REPORTS,5(0),12939.
MLA	Guo, Liyuan,et al."Network analysis reveals a stress-affected common gene module among seven stress-related diseases/systems which provides potential targets for mechanism research".SCIENTIFIC REPORTS 5.0(2015):12939.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
WOS_000359127400001.（704KB）	期刊论文	出版稿	暂不开放	CC BY-NC-SA	请求全文