Altered resting-state functional connectivity of the amygdala in Chinese earthquake survivors

doi:10.1016/j.pnpbp.2015.10.003

	Altered resting-state functional connectivity of the amygdala in Chinese earthquake survivors
	Zhang, Xiaoyu1,2 ; Zhang, Jianxin1 ; Wang, Li1 ; Li, Rui1 ; Zhang, Wencai1
摘要	Posttraumatic stress disorder (PTSD) is linked to abnormal amygdala activities. This study measured amygdala functional connectivity using DSM-5 criteria. There were 33 participants in the PTSD group and 33 participants in a trauma-exposed control (TEC) group, who did not have PTSD according to the PTSD checklist of the DSM-5 (PCL-5). Our findings are as follows: (1) In the PTSD group, the amygdala had increased positive connectivity with the medial prefrontal cortex (mPFC) and hippocampus, and decreased positive connectivity with the inferior mPFC and insula. The amygdala had increased negative connectivity with the orbital prefrontal cortex and decreased negative connectivity with the insula in comparison with TEC group. (2) PCL of all participants was correlated with the connectivity between the amygdala and the mPFC, hippocampus, and insula. These regions overlapped with those identified in the between-group comparisons. However, there was no association between PCL of the PTSD group and connectivity in these regions. Abnormal functional connectivity between the amygdala and mPFC subdivisions, hippocampus, and insula reveals their importance in PTSD pathogenesis. (C) 2015 Elsevier Inc. All rights reserved.
关键词	PTSD DSM-5 Resting-state functional connectivity Amygdala Medial prefrontal cortex
	2016-02-04
语种	英语
DOI	10.1016/j.pnpbp.2015.10.003
发表期刊	PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
ISSN	0278-5846
卷号	65 期号:0 页码:208-214
期刊论文类型	Article
收录类别	SCI
WOS关键词	POSTTRAUMATIC-STRESS-DISORDER ; PREFRONTAL CORTEX ; NEUROCIRCUITRY MODELS ; FMRI ; FLUCTUATIONS ; TOMOGRAPHY ; COGNITION ; SYMPTOMS ; INSIGHTS ; EMOTION
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目	Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号	WOS:000366709200024
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/15441
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.UCAS, Beijing 101408, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Zhang, Xiaoyu,Zhang, Jianxin,Wang, Li,et al. Altered resting-state functional connectivity of the amygdala in Chinese earthquake survivors[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2016,65(0):208-214.
APA	Zhang, Xiaoyu,Zhang, Jianxin,Wang, Li,Li, Rui,&Zhang, Wencai.(2016).Altered resting-state functional connectivity of the amygdala in Chinese earthquake survivors.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,65(0),208-214.
MLA	Zhang, Xiaoyu,et al."Altered resting-state functional connectivity of the amygdala in Chinese earthquake survivors".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 65.0(2016):208-214.

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