The Wada test is the only technology to mimic the brain lesions or surgical removal of brain lesions in preoperative evaluation of epilepsy.The epilepsy centers need to organize neuropsychological professionals, EEG experts, digital subtraction cerebral angiography (DSA) Branch and anesthesia experts to perform the Wada test. X-ray test is required to guild the catheters inserted from the femoral artery to the internal carotid artery cerebral to perform DSA, then short-acting anesthetics will be injected through the catheters to the brain hemispheres.After a temporary sleep the language，memory and motor function of the contralateral hemisphere will be tested. Testing the language dominant hemisphere is to prevent epileptic aphasia after surgery, while the memory assessment can effectively prevent postoperative loss of memory. on the basis of differences in memory tests in the cerebral hemispheres scores also can help the lateralization of epileptogenic focus and the forecast level of postoperative seizure relief. As a pioneering work in China,we have to explore the choice of anesthetic and the test procedures.In this study,we select propofol as short-acting anesthetic with the initial dose of propofol is 3-12mg. In this 8 refrectory epilepsy patients group,We assessed their language、motor memory and other functions in Wada test. Motor function: motor function of limbs is dominated by the Contralateral hemisphere in six of the seven patients .Languages function: one patient without language test and two patients with atypical language dominant hemisphere, that the right hemisphere for the language dominant hemisphere, other five patients were left hemisphere dominant hemisphere in language . Memory functon: Memory function can not be tested in 4 patients with mental retardation and the memory tests are not sufficient in other 4 patients. Location of epileptic foci: two of three patients for the hemispherectomy cancel the surgery after the Wada test because of the motor function of the ipsilateral, while one case of ipsilateral underwent almost no functional resection of the right hemisphere. Prediction of postoperative seizure relief: A patient with resection of the right hemisphere has a good seizure control.His cognitive function and motor function did not change significantly. Complications: Adverse reactions of Propofol were seen in 7 patients, most showed tonic seizures ,eye pain, flushing, tears.
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