Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence

doi:10.1016/j.bbr.2016.07.025

	Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence
	Li, Man 1; Du, Wei 1; Shao, Feng 1; Wang, Weiwen2
通讯作者邮箱	[email protected] ; [email protected]
摘要	Early life adversity, such as social isolation, causes a variety of changes to the development of cognitive abilities and the nervous system. Increasing evidence has shown that epigenetic modifications mediate gene-environment interactions throughout the lifespan. In this study, we investigated the effect of adolescent social isolation on cognitive behaviours and epigenetic alterations of the brain-derived neurotrophic factor (BDNF) gene. Male Sprague Dawley rats were randomly assigned to either group reared or isolation-reared conditions during post-natal days (PNDs) 21-34. On PND 56, all rats underwent behavioural testing and were then sacrificed for biochemical testing. Adolescent social isolation induced impaired PPI. Regarding BDNF, the isolation-reared rats demonstrated increased BDNF mRNA levels, H3 acetylation at the BDNF gene and BDNF protein expression in the medial prefrontal cortex (mPFC). In contrast, the BDNF mRNA levels, H3 acetylation of the BDNF gene and BDNF protein expression were decreased in the hippocampus of the isolation-reared rats. The present study indicated that epigenetic regulation of BDNF may be one of the molecular mechanisms that mediated the cognitive dysfunction. Moreover, the interaction between the mPFC and hippocampus might play an important role in the regulation of cognitive behaviour. (C) 2016 Elsevier B.V. All rights reserved.
关键词	Social Isolation Cognitive Behaviour Brain-derived Neurotrophic Factor (Bdnf) Epigenetics
	2016-10-15
语种	英语
DOI	10.1016/j.bbr.2016.07.025
发表期刊	BEHAVIOURAL BRAIN RESEARCH
ISSN	0166-4328
卷号	313 期号:0 页码:177-183
期刊论文类型	Article
收录类别	SCI
WOS关键词	MEDIAL PREFRONTAL CORTEX ; NEUROTROPHIC FACTOR EXPRESSION ; SPATIAL MEMORY PERFORMANCE ; ACOUSTIC STARTLE RESPONSE ; PREPULSE INHIBITION ; ADULT RATS ; MATERNAL SEPARATION ; VENTRAL HIPPOCAMPUS ; THETA-OSCILLATIONS ; NUCLEUS-ACCUMBENS
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology
WOS类目	Behavioral Sciences ; Neurosciences
WOS记录号	WOS:000382413800021
资助机构	National Natural Science Foundation of China(31470988 ; School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, the Chinese Academy of Sciences(KJZD-EW-L04) ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; 81471122)
引用统计	被引频次：42[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/20535
专题	中国科学院心理健康重点实验室
通讯作者	Shao, Feng; Wang, Weiwen
作者单位	1.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Sch Psychol & Cognit Sci, 5 Yiheyuan Rd, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
通讯作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Li, Man,Du, Wei,Shao, Feng,et al. Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence[J]. BEHAVIOURAL BRAIN RESEARCH,2016,313(0):177-183.
APA	Li, Man,Du, Wei,Shao, Feng,&Wang, Weiwen.(2016).Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence.BEHAVIOURAL BRAIN RESEARCH,313(0),177-183.
MLA	Li, Man,et al."Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence".BEHAVIOURAL BRAIN RESEARCH 313.0(2016):177-183.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Cognitive dysfunctio（868KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	请求全文