A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers

doi:10.3389/fnagi.2016.00231

	A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers
	Wu, Xia 1,2; Li, Qing 1; Yu, Xinyu 1; Chen, Kewei 3,4; Fleisher, Adam S.3,4,5; Guo, Xiaojuan 1; Zhang, Jiacai 1; Reiman, Eric M.3,4; Yao, Li 1,2; Li, Rui6
通讯作者邮箱	[email protected]
摘要	The triple network model, consisting of the central executive network (CEN), salience network (SN) and default mode network (DMN), has been recently employed to understand dysfunction in core networks across various disorders. Here we used the triple network model to investigate the large-scale brain networks in cognitively normal apolipoprotein e4 (APOE4) carriers who are at risk of Alzheimers disease (AD). To explore the functional connectivity for each of the three networks and the effective connectivity among them, we evaluated 17 cognitively normal individuals with a family history of AD and at least one copy of the APOE4 allele and compared the findings to those of 12 individuals who did not carry the APOE4 gene or have a family history of AD, using independent component analysis (ICA) and Bayesian network (BN) approach. Our findings indicated altered within-network connectivity that suggests future cognitive decline risk, and preserved between-network connectivity that may support their current preserved cognition in the cognitively normal APOE4 allele carriers. The study provides novel sights into our understanding of the risk factors for AD and their influence on the triple network model of major psychopathology.
关键词	Alzheimer's Disease APOE4 Bayesian network connectivity fMRI triple network model
	2016-09-28
语种	英语
DOI	10.3389/fnagi.2016.00231
发表期刊	FRONTIERS IN AGING NEUROSCIENCE
ISSN	1663-4365
卷号	8 期号:0 页码:1-9
期刊论文类型	Article
收录类别	SCI
WOS关键词	DEFAULT-MODE NETWORK ; INDEPENDENT COMPONENT ANALYSIS ; RESTING-STATE FMRI ; ALZHEIMERS-DISEASE ; FUNCTIONAL CONNECTIVITY ; FRONTOTEMPORAL DEMENTIA ; IMPAIRMENT ; MEMORY ; RISK ; MRI
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Geriatrics & Gerontology ; Neurosciences & Neurology
WOS类目	Geriatrics & Gerontology ; Neurosciences
WOS记录号	WOS:000384137400001
资助机构	National Institute on Aging(k23 AG024062) ; Funds for International Cooperation and Exchange of the National Natural Science Foundation of China(61210001) ; General Program of National Natural Science Foundation of China(61571047 ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences(KLMH2014ZG03 ; 31200847) ; KLMH2015G06)
引用统计	被引频次：35[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/20541
专题	中国科学院心理健康重点实验室
通讯作者	Li, Rui
作者单位	1.Beijing Normal Univ, Coll Informat Sci & Technol, Beijing, Peoples R China 2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China 3.Banner Alzheimers Inst, Phoenix, AZ USA 4.Banner Good Samaritan PET Ctr, Phoenix, AZ USA 5.Eli Lilly & Co, Indianapolis, IN 46285 USA 6.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Ctr Aging Psychol, Beijing, Peoples R China
通讯作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Wu, Xia,Li, Qing,Yu, Xinyu,et al. A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers[J]. FRONTIERS IN AGING NEUROSCIENCE,2016,8(0):1-9.
APA	Wu, Xia.,Li, Qing.,Yu, Xinyu.,Chen, Kewei.,Fleisher, Adam S..,...&Li, Rui.(2016).A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers.FRONTIERS IN AGING NEUROSCIENCE,8(0),1-9.
MLA	Wu, Xia,et al."A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers".FRONTIERS IN AGING NEUROSCIENCE 8.0(2016):1-9.

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A Triple Network Con（2260KB）	期刊论文	作者接受稿	限制开放	CC BY-NC-SA	请求全文