Objective: 1. To evaluate the short-term efficacy of Morita therapycombined with drug treatment in the patients with depression. 2. To evaluate the long-term efficacy of Morita therapycombined with drug treatment in the patients with depression. 3. To explore the difference between inpatient Morita therapy and outpatient Morita therapy. Methods: 60 outpatients（Outpatient Group） and 60 inpatients (Inpatient Group) with depression in Zibo Mental Health Center were randomly assigned to study groups and control groups separately, 30 cases each. The study groups received drug treatment and Morita therapy, while the control groups received drug treatment only for 8 weeks, then follow up 3 months. Before and after 8-week treatment and follow-up 3-month, four groups were assessed with the Hamilton Depression Scale, Simplified Coping Style Questionnaire and Outcomes Study Short-form 36. Result: 1. The short-term efficacy (after 8-week treatment): (1) The scores of the Hamilton Depression Scale in the study group were lower than that in the control groups (P<0.01). (2) The scores of positive style of Simplified Copy Style Questionnaire in the study groups were higher than that in the control groups (P<0.05)，and the scores of negative style were lower than that in the control groups (P<0.05). (3) Outpatient Group: the scores of physical functioning、social functioning、bodily pain and mental health in the Outcomes Study Short-form of the study group were higher than that of the control group (P<0.05 or P<0.01). Inpatient Group: the scores of physical functioning、social functioning and bodily pain of study group were higher than control group (P<0.05 or P<0.01). 2. The long-term efficacy (follow-up 3-month): (1) The scores of the Hamilton Depression Scale in the study groups were lower than in the control groups (P<0.01). (2) The scores of positive style of Simplified Copy Style Questionnaire in the study groups were higher than that in the control groups (P<0.05). (3) Outpatient group: the scores of social functioning、bodily pain、vitality and bodily pain in the Outcomes Study Short-form of the study group were higher than that of the control group (P<0.05 or P<0.01). Inpatient group: the scores of physical functioning、mental health and general health were higher than control group in follow-up 3-month (P<0.05 or P<0.01). 3. In the Outcomes Study Short-form, the score of social functioning of inpatient Morita therapy was higher than outpatient Morita therapy after 8-week treatment; The scores of body pain and mental health in the inpatient Morita therapy were higher than outpatient Morita therapy after follow-up 3-month(P<0.05 ). Conclusion: 1. The short-term efficacy of Morita therapycombined with drug treatment is better than mono-drug treatment in the Patients with Depression. 2. The long-term efficacy of Morita therapycombined with drug treatment is better than mono-drug treatment in the Patients with Depression. 3. Inpatient Morita therapy is better than outpatient Morita therapy in the efficacy of improving the quality of life.
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