健康与遗传心理学研究室知识库

目的考察合欢花总黄酮的抗焦虑作用。方法雄性ICR小鼠正常组、合欢花黄酮组(2.5、5.0、10.0 g·kg^-1)、阳性药物地西泮组各14只。连续给药7天后,采用高架十字迷宫(EPM)焦虑动物模型和明暗箱(LDB)焦虑动物模型,观察合欢花总黄酮对小鼠行为学的影响。结果合欢花总黄酮低、中、高剂量组小鼠进入开臂次数百分比(OE%)和在开臂时间百分比(OT%)均显著高于对照组(P〈0.05)。明暗箱实验中合欢花总黄酮低剂量组进入明箱次数和明箱活动时间显著高于对照组(P〈0.05)。结论合欢花总黄酮在高架十字迷宫模型和明暗箱模型均显示出抗焦虑作用,其抗焦虑作用机制有待于进一步探讨。

Objective This study aimed to evaluate the anxiolytic potential of the flowers of Albizia julibrissin Durazz. Methods 14 male ICR mice in each groups, the total flavonoids groups(2.5 、 5.0、 10.0 g·kg^-1) in comparison to diazepam using the elevated plus maze and light and dark box in mice after 7 days' administration. Results The total flavonoids of flowers of Albiziajulibrissin Durazz. increased the percentage of time spent and entries in the open arms in EPM test. Those dose also increase the time and entries in light box compare to the control group in LDB test. Conclusion The total flavonoids of the flowers of Albiziajulibrissin Durazz. had anti-anxiety effect.