Impaired Functional Criticality of Human Brain during Alzheimer's Disease Progression

doi:10.1038/s41598-018-19674-7

	Impaired Functional Criticality of Human Brain during Alzheimer's Disease Progression
	Jiang, Lili1,2,3 ; Sui, Danyang 1,2,4; Qiao, Kaini 1,2,4; Dong, Hao-Ming 1,2,4; Chen, Luonan 5; Han, Ying 6,7,8,9,10,11; Jiang Lili; Han Ying
第一作者	Jiang Lili
心理所单位排序	1
摘要	The progression of Alzheimer's Disease (AD) has been proposed to comprise three stages, subjective cognitive decline (SCD), mild cognitive impairment (MCI), and AD. Was brain dynamics across the three stages smooth? Was there a critical transition? How could we characterize and study functional criticality of human brain? Based on dynamical characteristics of critical transition from nonlinear dynamics, we proposed a vertex-wise Index of Functional Criticality (vIFC) of fMRI time series in this study. Using 42 SCD, 67 amnestic MCI (aMCI), 34 AD patients as well as their age-, sex-, years of education-matched 54 NC, our new method vIFC successfully detected significant patient-normal differences for SCD and aMCI, as well as significant negative correlates of vIFC in the right middle temporal gyrus with total scores of Montreal Cognitive Assessment (MoCA) in SCD. In comparison, standard deviation of fMRI time series only detected significant differences between AD patients and normal controls. As an index of functional criticality of human brain derived from nonlinear dynamics, vIFC could serve as a sensitive neuroimaging marker for future studies; considering much more vIFC impairments in aMCI compared to SCD and AD, our study indicated aMCI as a critical stage across AD progression.
	2018-01-22
语种	英语
DOI	10.1038/s41598-018-19674-7
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	8 期号:1 页码:doi: 10. 1038/s41598-018-19674-7
期刊论文类型	Article
收录类别	SCI ; SSCI
WOS关键词	MILD COGNITIVE IMPAIRMENT ; SUBJECTIVE MEMORY IMPAIRMENT ; SURFACE-BASED ANALYSIS ; DECLINE ; BIOMARKERS ; CORTEX ; CONNECTIVITY ; TASK
WOS标题词	Science & Technology
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000422912100007
Q分类	Q1
资助机构	National Natural Science Foundation of China(11674388 ; Startup Foundation for Young Talents of the Institute of Psychology(Y1CX222005) ; National Key Basic Research and Development (973) Program(2015CB351702) ; National Key Research and Development Program of China(2016YFC1306300) ; Beijing Nature Science Foundation(7161009) ; Beijing Municipal Science & Technology Commission(Z161100002616020) ; Capital Medical University(16JL-L08) ; 11204369 ; 81471740 ; 31371007 ; 81430037 ; 61633018)
引用统计	被引频次：25[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/25700
专题	中国科学院行为科学重点实验室
通讯作者	Jiang Lili; Han Ying
作者单位	1.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Lifespan Connect & Behav Team, Beijing 100101, Peoples R China 3.Princeton Univ, Princeton Neurosci Inst, Princeton, NJ 08544 USA 4.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Innovat Ctr Cell Signaling Network, Inst Biochem & Cell Biol,Key Lab Syst Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China 6.Capital Med Univ, XuanWu Hosp, Dept Neurol, Beijing 100053, Peoples R China 7.Ctr Alzheimers Dis, Beijing 100053, Peoples R China 8.Inst Brain Disorders, Beijing 100053, Peoples R China 9.Beijing Inst Geriatr, Beijing 100053, Peoples R China 10.Natl Clin Res Ctr Geriatr Disorders, Beijing, Peoples R China 11.PKU Care Rehabil Hosp, Beijing 100053, Peoples R China
第一作者单位	中国科学院行为科学重点实验室
推荐引用方式 GB/T 7714	Jiang, Lili,Sui, Danyang,Qiao, Kaini,et al. Impaired Functional Criticality of Human Brain during Alzheimer's Disease Progression[J]. SCIENTIFIC REPORTS,2018,8(1):doi: 10. 1038/s41598-018-19674-7.
APA	Jiang, Lili.,Sui, Danyang.,Qiao, Kaini.,Dong, Hao-Ming.,Chen, Luonan.,...&Han Ying.(2018).Impaired Functional Criticality of Human Brain during Alzheimer's Disease Progression.SCIENTIFIC REPORTS,8(1),doi: 10. 1038/s41598-018-19674-7.
MLA	Jiang, Lili,et al."Impaired Functional Criticality of Human Brain during Alzheimer's Disease Progression".SCIENTIFIC REPORTS 8.1(2018):doi: 10. 1038/s41598-018-19674-7.

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vIFC_SCD_aMCI_AD.pdf（2887KB）	期刊论文	出版稿	暂不开放	CC BY-NC-SA	请求全文