High-functioning autism patients share similar but more severe impairments in verbal theory of mind than schizophrenia patients

doi:10.1017/S0033291717002690

	High-functioning autism patients share similar but more severe impairments in verbal theory of mind than schizophrenia patients
	Tin, L. N. W.1; Lui, S. S. Y.1,2; Ho, K. K. Y.1; Hung, K. S. Y.1; Wang, Y.2 ; Yeung, H. K. H.1; Wong, T. Y.1,3; Lam, S. M.1; Chan, R. C. K.2,4 ; Cheung, E. F. C.1
摘要	Background. Evidence suggests that autism and schizophrenia share similarities in genetic, neuropsychological and behavioural aspects. Although both disorders are associated with theory of mind (ToM) impairments, a few studies have directly compared ToM between autism patients and schizophrenia patients. This study aimed to investigate to what extent high-functioning autism patients and schizophrenia patients share and differ in ToM performance. Methods. Thirty high-functioning autism patients, 30 schizophrenia patients and 30 healthy individuals were recruited. Participants were matched in age, gender and estimated intelligence quotient. The verbal-based Faux Pas Task and the visual-based Yoni Task were utilised to examine first- and higher-order, affective and cognitive ToM. The task/item difficulty of two paradigms was examined using mixed model analyses of variance (ANOVAs). Multiple ANOVAs and mixed model ANOVAs were used to examine group differences in ToM. Results. The Faux Pas Task was more difficult than the Yoni Task. High-functioning autism patients showed more severely impaired verbal-based ToM in the Faux Pas Task, but shared similar visual-based ToM impairments in the Yoni Task with schizophrenia patients. Conclusions. The findings that individuals with high-functioning autism shared similar but more severe impairments in verbal ToM than individuals with schizophrenia support the autism-schizophrenia continuum. The finding that verbal-based but not visual-based ToM was more impaired in high-functioning autism patients than schizophrenia patients could be attributable to the varied task/item difficulty between the two paradigms.
关键词	High-functioning autism mentalising schizophrenia theory of mind
	2018-06-01
语种	英语
DOI	10.1017/S0033291717002690
发表期刊	PSYCHOLOGICAL MEDICINE
ISSN	0033-2917
卷号	48 期号:8 页码:1264-1273
资助项目	Beijing Municipal Science & Technology Commission Grant[Z161100000216138] ; Beijing Training Project for the Leading Talents in S T[Z151100000315020] ; National Science Fund China[31400884]
出版者	CAMBRIDGE UNIV PRESS
WOS关键词	ASPERGERS-SYNDROME ; CHILDHOOD PSYCHOSES ; SPECTRUM DISORDERS ; PREFRONTAL LESIONS ; NEGATIVE SYMPTOMS ; FRONTAL-LOBE ; METAANALYSIS ; ADOLESCENTS ; CHILDREN ; CLASSIFICATION
WOS研究方向	Psychology ; Psychiatry
WOS类目	Psychology, Clinical ; Psychiatry ; Psychology
WOS记录号	WOS:000432396700004
资助机构	Beijing Municipal Science & Technology Commission Grant ; Beijing Training Project for the Leading Talents in S T ; National Science Fund China
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/25746
专题	中国科学院心理健康重点实验室健康与遗传心理学研究室
通讯作者	Lui, S. S. Y.
作者单位	1.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China 3.Rhein Westfal TH Aachen, Aachen, Germany 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
通讯作者单位	认知与发展心理学研究室
推荐引用方式 GB/T 7714	Tin, L. N. W.,Lui, S. S. Y.,Ho, K. K. Y.,et al. High-functioning autism patients share similar but more severe impairments in verbal theory of mind than schizophrenia patients[J]. PSYCHOLOGICAL MEDICINE,2018,48(8):1264-1273.
APA	Tin, L. N. W..,Lui, S. S. Y..,Ho, K. K. Y..,Hung, K. S. Y..,Wang, Y..,...&Cheung, E. F. C..(2018).High-functioning autism patients share similar but more severe impairments in verbal theory of mind than schizophrenia patients.PSYCHOLOGICAL MEDICINE,48(8),1264-1273.
MLA	Tin, L. N. W.,et al."High-functioning autism patients share similar but more severe impairments in verbal theory of mind than schizophrenia patients".PSYCHOLOGICAL MEDICINE 48.8(2018):1264-1273.

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