Association of schizotypy with striatocortical functional connectivity and its asymmetry in healthy adults

doi:10.1002/hbm.23842

	Association of schizotypy with striatocortical functional connectivity and its asymmetry in healthy adults
	Wang, Yi1 ; Ettinger, Ulrich 2; Meindl, Thomas 3; Chan, Raymond C. K.1,4 ; Chan, Raymond C K
第一作者	Wang, Yi
通讯作者邮箱	[email protected] ; [email protected]
心理所单位排序	1
摘要	Altered striatocortical functional connectivity has been suggested to be a trait marker of schizophrenia spectrum disorders, including schizotypal personality. In the present study, we examined the association between schizotypal personality traits and striatocortical functional connectivity in a sample of healthy adults. The German version of the Schizotypal Personality Questionnaire was obtained from N=111 participants recruited from the general public. Resting-state functional magnetic resonance imaging scans were acquired at 3T. Six striatal seed regions in each hemisphere were defined and striatocortical resting-state functional connectivity (rsFC) as well as its lateralization indices was calculated. Regression analysis showed that schizotypy scores, especially from the positive dimension, were positively correlated with rsFC between ventral striatum and frontal cortex and negatively associated with rsFC between dorsal striatum and posterior cingulate. No significant associations were found between negative dimension schizotypy and striatocortical rsFC. We also found positive correlations between schizotypy total scores and lateralization index of right dorsal caudate and right rostral putamen. In conclusion, the present study extends previous evidence of altered striatocortical rsFC in the schizophrenia spectrum. The observed associations resemble in part the alterations observed in psychotic patients and their relatives, providing support for dimensionality from schizotypal personality to the clinical disorder. Hum Brain Mapp 39:288-299, 2018. (c) 2017 Wiley Periodicals, Inc.
关键词	schizotypy functional magnetic resonance imaging resting state connectivity striatum lateralization
	2018
语种	英语
DOI	10.1002/hbm.23842
发表期刊	HUMAN BRAIN MAPPING
ISSN	1065-9471
卷号	39 期号:1 页码:288-299
期刊论文类型	Article
收录类别	SCI
WOS关键词	III-R CRITERIA ; PSYCHOMETRIC SCHIZOTYPY ; CORTICOSTRIATAL CIRCUITRY ; NEGATIVE SCHIZOTYPY ; BRAIN STRUCTURE ; EYE TRACKING ; CANNABIS USE ; SCHIZOPHRENIA ; PERSONALITY ; PSYCHOSIS
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000417282000019
Q分类	Q1
资助机构	DFG(Et 31/2-1) ; National Basic Research Programme of China(2016YFC0906402) ; Beijing Training Project for Leading Talents in ST(Z151100000315020) ; Beijing Municipal Science & Technology Commission(Z161100000216138) ; National Science Fund China(81571317 ; China Scholarship Council ; 31400884)
引用统计	被引频次：24[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/25748
专题	中国科学院心理健康重点实验室健康与遗传心理学研究室
通讯作者	Ettinger, Ulrich; Chan, Raymond C K
作者单位	1.CAS Key Lab Mental Hlth, Inst Psychol, Neuropsychol & Appl Cognit Neurosci NACN Lab, Beijing, Peoples R China 2.Univ Bonn, Dept Psychol, Kaiser Karl Ring 9, D-53111 Bonn, Germany 3.Univ Munich, Inst Clin Radiol, Munich, Germany 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yi,Ettinger, Ulrich,Meindl, Thomas,et al. Association of schizotypy with striatocortical functional connectivity and its asymmetry in healthy adults[J]. HUMAN BRAIN MAPPING,2018,39(1):288-299.
APA	Wang, Yi,Ettinger, Ulrich,Meindl, Thomas,Chan, Raymond C. K.,&Chan, Raymond C K.(2018).Association of schizotypy with striatocortical functional connectivity and its asymmetry in healthy adults.HUMAN BRAIN MAPPING,39(1),288-299.
MLA	Wang, Yi,et al."Association of schizotypy with striatocortical functional connectivity and its asymmetry in healthy adults".HUMAN BRAIN MAPPING 39.1(2018):288-299.

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