Institutional Repository of Key Laboratory of Mental Health, CAS
Interactive effects of corticotropin-releasing hormone receptor 1 gene and work stress on burnout in medical professionals in a Chinese Han population | |
He Shu-Chang1; Wu Shuang1; Du Xiang-Dong2; Jia Qiufang2; Wang Chao1; Wu Fengchun3; Ning Yuping3; Wang Dongmei4![]() ![]() ![]() | |
第一作者 | He Shu-Chang |
通讯作者邮箱 | s.-c. he([email protected] ) ; x.y. zhang([email protected]) |
心理所单位排序 | 2 |
摘要 | Background: Burnout is a worked-related stress syndrome caused by long-term exposure to a stressful environment. Dysregulation of the hypothalamic- pituitary- adrenal (HPA) axis may be involved in both stress and burnout; an evaluation of genetic polymorphisms which alter activity in the HPA may be predictive of how likely an environment is to produce burnout. Methods: Using a cross-sectional design, this study examined whether corticotrophin-releasing hormone receptor 1 (CRHR1) gene polymorphism rs110402 is a risk factor for burnout; further, it explores whether the interaction of stress x CRHR1 gene predicts burnout in the healthcare workers in a Chinese Han population. House and Rizzo's work stress scale, Sources of Pressure Scale and Maslach Burnout Inventory-General Survey were administered to 712 participants from a large general hospital in Beijing. The CRHR1 rs110402 polymorphism was genotyped in 376 participants. Results: Our results showed significant positive inter-correlations between stressor, work stress and depressive scores (all p < 0.001) with only one exception. Males, younger age and higher educational level were associated with burnout (all p < 0.05). The presence of the CRHR1 rs110402 genotype was not correlated with the presence of job stress or burnout. However, we found statistically significant interaction between CRHR1 rs110402 and job stress on burnout (p < 0.05). Individuals homozygous for the A allele reported significantly higher emotional exhaustion than G allele carriers in the high stress group. Limitations: The sample was only chosen from the medical professions, and the sample size was relatively small. Only one polymorphism in CRHR1 gene was analyzed, while only about half of the total individuals were genotyped. Conclusions: Our results suggest a close relationship between work-related stress and burnout and that the A allele of the CRHR1 rs110402 polymorphism may enhance feelings of emotional exhaustion when experiencing work-related stress. |
关键词 | Burnout Stress Corticotrophin-releasing hormone receptor Genotype Interaction |
2019-06-01 | |
语种 | 英语 |
DOI | 10.1016/j.jad.2019.03.084 |
发表期刊 | JOURNAL OF AFFECTIVE DISORDERS
![]() |
ISSN | 0165-0327 |
卷号 | 252页码:1-8 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[81271491] ; National Natural Science Foundation of China[81571322] ; National Natural Science Foundation of China[81371477] |
出版者 | ELSEVIER SCIENCE BV |
WOS关键词 | DEPRESSIVE SYMPTOMS ; ADULT DEPRESSION ; JOB-SATISFACTION ; CORTISOL ; ASSOCIATION ; SUSCEPTIBILITY ; EXHAUSTION ; HEALTH ; CRHR1 ; RISK |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
WOS类目 | Clinical Neurology ; Psychiatry |
WOS记录号 | WOS:000467801200001 |
资助机构 | National Natural Science Foundation of China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/29263 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | He Shu-Chang; Zhang Xiang Yang |
作者单位 | 1.School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing 2.Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Jiangsu, China 3.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China 4.CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Science, Beijing, China |
推荐引用方式 GB/T 7714 | He Shu-Chang,Wu Shuang,Du Xiang-Dong,et al. Interactive effects of corticotropin-releasing hormone receptor 1 gene and work stress on burnout in medical professionals in a Chinese Han population[J]. JOURNAL OF AFFECTIVE DISORDERS,2019,252:1-8. |
APA | He Shu-Chang.,Wu Shuang.,Du Xiang-Dong.,Jia Qiufang.,Wang Chao.,...&Zhang Xiang Yang.(2019).Interactive effects of corticotropin-releasing hormone receptor 1 gene and work stress on burnout in medical professionals in a Chinese Han population.JOURNAL OF AFFECTIVE DISORDERS,252,1-8. |
MLA | He Shu-Chang,et al."Interactive effects of corticotropin-releasing hormone receptor 1 gene and work stress on burnout in medical professionals in a Chinese Han population".JOURNAL OF AFFECTIVE DISORDERS 252(2019):1-8. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Interactive effects (535KB) | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论