The brain default mode network (DMN)is thought to play roles in internal mentation and spontaneous cogniton. Aberrant default-mode functional connectivity has been reported in a host of neurological and psychitric illness and in persons at genetic risk for such illness. Whereas the neurophysiological mechanisms underlying the default-mode connectivity are unclear, there is growing evidence that genetic factors play a role. In this study, we aim to estimate the relative contribution of genetic and environmental factors to individual differences in default-mode functional connectivity by employing a resting-state fMRI twin study.Subjects were 180 pairs of healthy same-sex adolescent twins aged 15 to 17 years old. The low frequency （0.01-0.08 Hz）BOLD signal time series were extrated from 11 regions of interest (ROI)in DMN.Pearson correlation coefficients were computed between each pairs of ROIs to represent the intensity of functional connectivity.The genetic and enviornmental contributions to default-mode functional connectivities were estimated by twin statistical models. This study can help us understand the origins of individual differences in default-mode functional connectivity. The estimates of heritability of default-mode functional connectivity can provide evidence required before it can be considered as e
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