Associations of cortical thickness, surface area and subcortical volumes with insight in drug-naive adults with obsessive-compulsive disorder

doi:10.1016/j.nicl.2019.102037

	Associations of cortical thickness, surface area and subcortical volumes with insight in drug-naive adults with obsessive-compulsive disorder
	Liu, Wanting 1,2; Gan, Jun 1; Fan, Jie 1; Zheng, Hong 1; Li, Sihui 1; Chan, Raymond C. K.3,4 ; Tan, Changlian 5; Zhu, Xiongzhao 1,2
通讯作者	Tan, Changlian([email protected]) ; Zhu, Xiongzhao([email protected])
摘要	Poor insight in obsessive-compulsive disorder (OCD) is associated with several adverse clinical outcomes. However, the neurobiological basis of this insight deficit is not clearly understood. The present study thus aimed to investigate associations of cortical thickness, cortical surface area and subcortical volumes with insight in a sample of drug-naive adults with OCD. Forty-seven OCD patients and 42 healthy controls (HCs) underwent MRI scanning, depression and anxiety assessments. The Brown Assessment of Beliefs Scale (BABS) measured insight levels and patients were divided into two groups: poor insight (OCD-PI; n = 21), and good insight (OCD-GI; n = 26). Cortical thickness and surface area between groups were compared with whole-brain exploratory vertex-by-vertex analyses, while subcortical volumes were compared on a structure-by-structure basis. Partial correlation analyses were then performed to assess associations between regional cortical and subcortical measures and insight levels. OCD-GI and OCD-PI groups displayed partly shared, but also partly distinct brain structural alterations. Strikingly, OCD-PI showed decreased cortical thickness in the left superior frontal gyrus, left anterior cingulate cortex (ACC) and right inferior parietal gyrus, compared to both OCD-GI and HCs. Average cortical thickness extracted from these areas was further negatively correlated with BABS scores in the OCD-PI patients. Our findings suggest that poor insight in patients with OCD may have a neural substrate involving the left medial frontal and the right inferior parietal cortices.
关键词	Obsessive-compulsive disorder Insight Cortical thickness Surface-based morphometry
	2019
语种	英语
DOI	10.1016/j.nicl.2019.102037
发表期刊	NEUROIMAGE-CLINICAL
ISSN	2213-1582
卷号	24 页码:8
收录类别	SCI
资助项目	National Key Technology Research and Development Program of the Ministry of Science and Technology of China[2012BA136B01] ; Beijing Training Project for the Leading Talents in ST[Z151100000315020] ; Strategic Priority Research Program (B) of the Chinese Academy of Science[XDB02030002]
出版者	ELSEVIER SCI LTD
WOS关键词	ANTERIOR CINGULATE CORTEX ; INFERIOR PARIETAL LOBULE ; POOR INSIGHT ; COGNITIVE INSIGHT ; SELF-REFLECTION ; CEREBRAL-CORTEX ; SCHIZOPHRENIA ; BRAIN ; ANOSOGNOSIA ; UNAWARENESS
WOS研究方向	Neurosciences & Neurology
WOS类目	Neuroimaging
WOS记录号	WOS:000504663800019
资助机构	National Key Technology Research and Development Program of the Ministry of Science and Technology of China ; Beijing Training Project for the Leading Talents in ST ; Strategic Priority Research Program (B) of the Chinese Academy of Science
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/30598
专题	中国科学院心理健康重点实验室
通讯作者	Tan, Changlian; Zhu, Xiongzhao
作者单位	1.Cent S Univ, Xiangya Hosp 2, Med Psychol Ctr, Changsha 410011, Hunan, Peoples R China 2.Cent S Univ, Inst Med Psychol, Changsha, Hunan, Peoples R China 3.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Cent S Univ, Xiangya Hosp 2, Dept Radiol, Changsha, Hunan, Peoples R China
推荐引用方式 GB/T 7714	Liu, Wanting,Gan, Jun,Fan, Jie,et al. Associations of cortical thickness, surface area and subcortical volumes with insight in drug-naive adults with obsessive-compulsive disorder[J]. NEUROIMAGE-CLINICAL,2019,24:8.
APA	Liu, Wanting.,Gan, Jun.,Fan, Jie.,Zheng, Hong.,Li, Sihui.,...&Zhu, Xiongzhao.(2019).Associations of cortical thickness, surface area and subcortical volumes with insight in drug-naive adults with obsessive-compulsive disorder.NEUROIMAGE-CLINICAL,24,8.
MLA	Liu, Wanting,et al."Associations of cortical thickness, surface area and subcortical volumes with insight in drug-naive adults with obsessive-compulsive disorder".NEUROIMAGE-CLINICAL 24(2019):8.