Prevalence and Prescription of Antidepressants in Depression with Somatic Comorbidity in Asia: The Research on East Asian Psychotropic Prescription Patterns Study

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	Prevalence and Prescription of Antidepressants in Depression with Somatic Comorbidity in Asia: The Research on East Asian Psychotropic Prescription Patterns Study
其他题名	Prevalence and Prescription of Antidepressants in Depression with Somatic Comorbidity in Asia: The Research on East Asian Psychotropic Prescription Patterns Study
	Chen Chao 1; Si TianMei 1; Xiang YuTao 3; Ungvari Gabor S 5; Wang ChuanYue 6; He YanLing 7; Kua EeHeok 8; Fujii Senta 9; Sim Kang 10; Trivedi Jitendra K 11; Chung EunKee 12; Udomratn Pichet 13; Chee KokYoon 14; Sartorius Norman 15; Tan ChayHoon 16; Shinfuku Naotaka 17
摘要	Background: Depression is often comorbid with chronic somatic diseases. Few previous studies have investigated the prevalence of somatic diseases in depression or the prescription pattern of antidepressants in comorbidly depressed patients in Asia. This study aimed to investigate the prevalence of somatic comorbidity (SC) in depression and compared the prescriptions of antidepressants in depressed patients with and without SC. Methods: A total of 2320 patients treated with antidepressants in 8 Asian countries were examined, and a diagnosis was based on the International Classification of Disease, 10 th revision. We listed 17 common chronic somatic diseases. Patients′ socio-demographic and clinical characteristics and psychotropic drug prescriptions were recorded using a standardized protocol and data collection procedure. Results: Of the patients examined, 1240 were diagnosed with depression and 30% of them (n = 375) had SC. The most common comorbid condition was diabetes (23.7%). The patients with SC were more likely to seek help at a general hospital (74.7% vs. 47.2%), and had a higher incidence of symptoms involving sadness, disturbed sleep, and poor appetite. Noradrenergic and specific serotonergic antidepressant was prescribed more for patients with SC than for those without SC (30.4% vs. 22.9%). Conclusions: SC is common in depressed Asian patients. It is important to strengthen the recognition of depression, especially in general hospitals and when patients report some somatic discomfort. It is also a matter of urgency to establish evidence-based guidelines for the use of new antidepressants in depressed patients with SC.
其他摘要	Background: Depression is often comorbid with chronic somatic diseases. Few previous studies have investigated the prevalence of somatic diseases in depression or the prescription pattern of antidepressants in comorbidly depressed patients in Asia. This study aimed to investigate the prevalence of somatic comorbidity (SC) in depression and compared the prescriptions of antidepressants in depressed patients with and without SC. Methods: A total of 2320 patients treated with antidepressants in 8 Asian countries were examined, and a diagnosis was based on the International Classification of Disease, 10 th revision. We listed 17 common chronic somatic diseases. Patients’ socio-demographic and clinical characteristics and psychotropic drug prescriptions were recorded using a standardized protocol and data collection procedure. Results: Of the patients examined, 1240 were diagnosed with depression and 30% of them ( n = 375) had SC. The most common comorbid condition was diabetes (23.7%). The patients with SC were more likely to seek help at a general hospital (74.7% vs. 47.2%), and had a higher incidence of symptoms involving sadness, disturbed sleep, and poor appetite. Noradrenergic and specific serotonergic antidepressant was prescribed more for patients with SC than for those without SC (30.4% vs. 22.9%). Conclusions: SC is common in depressed Asian patients. It is important to strengthen the recognition of depression, especially in general hospitals and when patients report some somatic discomfort. It is also a matter of urgency to establish evidence-based guidelines for the use of new antidepressants in depressed patients with SC.
关键词	Asia Medicine R Depression Prescription Prevalence Somatic Comorbidity
	2015
语种	英语
发表期刊	Chinese Medical Journal
ISSN	0366-6999
卷号	128 期号:7 页码:853-858
收录类别	CSCD
资助项目	["12th Five-year-plan" of National Key Technologies R and D Program of China] ; [Research Fund for the Doctoral Program of Higher Education of China]
CSCD记录号	CSCD:5392544
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/36515
专题	健康与遗传心理学研究室
作者单位	1.中国科学院心理研究所 2.北京大学 3.University Macau, Fac Hlth Sci, Macau, Peoples R China 4.Chinese University Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China Dept Psychiat 5.University Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia 6.Capital Med University, Beijing Anding Hosp, Beijing 100088, Peoples R China 7.Shanghai Mental Hlth Ctr, Shanghai 200030, Peoples R China 8.Natl University Singapore, Dept Psychol Med, Singapore 117548, Singapore 9.Fukushima Med University, Dept Disaster Psychiat, Fukushima, Japan 10.Institute Mental Hlth, Singapore, Singapore 11.CSM Med University, Dept Psychiat, Lucknow, Uttar Pradesh, India 12.Natl Seoul Hosp, Department Psychiat, Seoul, South Korea 13.Prince Songkla University, Fac Med, Dept Psychiat, Hat Yai, Thailand 14.Kuala Lumpur Hosp, Tunku Abdul Rahman Institute Neurosci, Dept Psychiat & Mental Hlth, Kuala Lumpur, Malaysia 15.Assoc Improvement Mental Hlth Programs, Geneva, Switzerland 16.安徽肥东花生原种场 17.西南学院大学
第一作者单位	中国科学院心理研究所
推荐引用方式 GB/T 7714	Chen Chao,Si TianMei,Xiang YuTao,et al. Prevalence and Prescription of Antidepressants in Depression with Somatic Comorbidity in Asia: The Research on East Asian Psychotropic Prescription Patterns Study[J]. Chinese Medical Journal,2015,128(7):853-858.
APA	Chen Chao.,Si TianMei.,Xiang YuTao.,Ungvari Gabor S.,Wang ChuanYue.,...&Shinfuku Naotaka.(2015).Prevalence and Prescription of Antidepressants in Depression with Somatic Comorbidity in Asia: The Research on East Asian Psychotropic Prescription Patterns Study.Chinese Medical Journal,128(7),853-858.
MLA	Chen Chao,et al."Prevalence and Prescription of Antidepressants in Depression with Somatic Comorbidity in Asia: The Research on East Asian Psychotropic Prescription Patterns Study".Chinese Medical Journal 128.7(2015):853-858.