Is Early-onset in Major Depression a Predictor of Specific Clinical Features with More Impaired Social Function?

PSYCH OpenIR > 健康与遗传心理学研究室

	Is Early-onset in Major Depression a Predictor of Specific Clinical Features with More Impaired Social Function?
其他题名	Is Early-onset in Major Depression a Predictor of Specific Clinical Features with More Impaired Social Function?
	Liu YanHong 1; Chen Lin 1; Su YunAi 2; Fang YiRu 3; Srisurapanont Manit 4; Hong Jin Pyo 5; Hatim Ahmad 6; Chua Hong Choon 7; Bautista Dianne 8; Si TianMei 2
摘要	Background: Early-onset major depressive disorder (MDD) (EOD) is often particularly malignant due to its special clinical features, accompanying impaired social function, protracted recovery time, and frequent recurrence. This study aimed to observe the effects of age onset on clinical characteristics and social function in MDD patients in Asia. Methods: In total, 547 out-patients aged 18-65 years who were from 13 study sites in five Asian countries were included. These patients had MDD diagnose according to the Diagnostic and Statistical Manual of Mental Disorders, 4 th Edition criteria. Clinical features and social function were assessed using Symptom Checklist-90-revised (SCL-90-R) and Sheehan Disability Scale (SDS). Quality of life was assessed by a 36-item Short-form Health Survey (SF-36). Analyses were performed using a continuous or dichotomous (cut-off: 30 years) age-of-onset indicator. Results: Early-onset MDD (EOD, <30 years) was associated with longer illness (P = 0.003), unmarried status (P < 0.001), higher neuroticism (P ≤ 0.002) based on the SCL-90-R, and more limited social function and mental health (P = 0.006, P = 0.007) based on the SF-36 and SDS. The impairment of social function and clinical severity were more prominent at in-patients with younger onset ages. Special clinical features and more impaired social function and quality of life were associated with EOD, as in western studies. Conclusions: EOD often follows higher levels of neuroticism. Age of onset of MDD may be a predictor of clinical features and impaired social function, allowing earlier diagnosis and treatment.
其他摘要	Background: Early-onset major depressive disorder (MDD) (EOD) is often particularly malignant due to its special clinical features, accompanying impaired social function, protracted recovery time, and frequent recurrence. This study aimed to observe the effects of age onset on clinical characteristics and social function in MDD patients in Asia. Methods: In total, 547 out-patients aged 18–65 years who were from 13 study sites in five Asian countries were included. These patients had MDD diagnose according to the Diagnostic and Statistical Manual of Mental Disorders, 4 th Edition criteria. Clinical features and social function were assessed using Symptom Checklist-90-revised (SCL-90-R) and Sheehan Disability Scale (SDS). Quality of life was assessed by a 36-item Short-form Health Survey (SF-36). Analyses were performed using a continuous or dichotomous (cut-off: 30 years) age-of-onset indicator. Results: Early-onset MDD (EOD, <30 years) was associated with longer illness ( P = 0.003), unmarried status ( P < 0.001), higher neuroticism ( P ≤ 0.002) based on the SCL-90-R, and more limited social function and mental health ( P = 0.006, P = 0.007) based on the SF-36 and SDS. The impairment of social function and clinical severity were more prominent at in-patients with younger onset ages. Special clinical features and more impaired social function and quality of life were associated with EOD, as in western studies. Conclusions: EOD often follows higher levels of neuroticism. Age of onset of MDD may be a predictor of clinical features and impaired social function, allowing earlier diagnosis and treatment.
关键词	Age Onset Medicine R Asia Clinical Features Major Depressive Disorder Social Function
	2015
语种	英语
发表期刊	Chinese Medical Journal
ISSN	0366-6999
卷号	128 期号:6 页码:811-815
收录类别	CSCD
CSCD记录号	CSCD:5363394
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/36713
专题	健康与遗传心理学研究室
作者单位	1.北京大学 2.中国科学院心理研究所 3.上海交通大学 4.清迈大学 5.Asan Med Ctr, Fac Med, Department Psychiat, Seoul, South Korea 6.University Malaya, Fac Med, Dept Psychol Med, Kuala Lumpur, Malaysia 7.Woodbridge Hosp, Institute Mental Hlth, Singapore, Singapore 8.Duke Natl University Singapore, Grad Sch Med, Off Clin Sci, Ctr Quantitat Med, Singapore, Singapore
推荐引用方式 GB/T 7714	Liu YanHong,Chen Lin,Su YunAi,et al. Is Early-onset in Major Depression a Predictor of Specific Clinical Features with More Impaired Social Function?[J]. Chinese Medical Journal,2015,128(6):811-815.
APA	Liu YanHong.,Chen Lin.,Su YunAi.,Fang YiRu.,Srisurapanont Manit.,...&Si TianMei.(2015).Is Early-onset in Major Depression a Predictor of Specific Clinical Features with More Impaired Social Function?.Chinese Medical Journal,128(6),811-815.
MLA	Liu YanHong,et al."Is Early-onset in Major Depression a Predictor of Specific Clinical Features with More Impaired Social Function?".Chinese Medical Journal 128.6(2015):811-815.