Expression of c-fos in Amygdala and Conditioned Immunosuppression

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	Expression of c-fos in Amygdala and Conditioned Immunosuppression
其他题名	Expression of c-fos in Amygdala and Conditioned Immunosuppression
	Zheng Li; Wang Weiwen; Lin Wenjuan; Li Jie; Chen Jihuan
摘要	By using c-fos protein production as a marker of neuronal activation, the present work attempts to localize the various subdivisions within the amygdala that may participate in the neural mechanism of conditioned immunosuppression (CIS) in a conditioned taste aversion (CTA) paradigm. CTA and CIS were established by intake of saccharin as the conditioned stimulus (CS) with an injection of cyclophosphamide as an unconditioned stimulus (UCS).After animals were re-exposed to CS alone at intervals of 5 or 30 days after two trials of CS-UCS pairing, both CTA and CIS were assessed and the expression of c-fos protein in the amygdala nucleus was also observed correspondingly. The results showed that CTA occurred on both day 5 and day 30 after conditioning but CIS occurred only on day 5 after conditioning. Furthermore, it was found dense c-fos expression in the amygdaloid central (CeA) in the CS group was observed at the 5 days interval and moderate c-fos immunoreactive inductions at the 30 days interval after re-exposure to CS. In the UCS group, low level of c-fos immunoreactive productions in the CeA were detected at either interval testing. By comparing the results of the 5th day with the 30th day, it suggests that the CeA is an important nucleus related to the modulation of CIS.
其他摘要	By using c-fos protein production as a marker of neuronal activation, the present work attempts to localize the various subdivisions within the amygdala that may participate in the neural mechanism of conditioned immunosuppression (CIS) in a conditioned taste aversion (CTA) paradigm. CTA and CIS were established by intake of saccharin as the conditioned stimulus (CS) with an injection of cyclophosphamide as an unconditioned stimulus (UCS).After animals were re-exposed to CS alone at intervals of 5 or 30 days after two trials of CS-UCS pairing, both CTA and CIS were assessed and the expression of c-fos protein in the amygdala nucleus was also observed correspondingly. The results showed that CTA occurred on both day 5 and day 30 after conditioning but CIS occurred only on day 5 after conditioning. Furthermore, it was found dense c-fos expression in the amygdaloid central (CeA) in the CS group was observed at the 5 days interval and moderate c-fos immunoreactive inductions at the 30 days interval after re-exposure to CS. In the UCS group, low level of c-fos immunoreactive productions in the CeA were detected at either interval testing. By comparing the results of the 5th day with the 30th day, it suggests that the CeA is an important nucleus related to the modulation of CIS.
关键词	条件反射性免疫抑制杏仁核大鼠
	2004
语种	英语
发表期刊	Acta Psychologica Sinica
ISSN	0439-755X
卷号	36 期号:4 页码:500-505
收录类别	CSCD
CSCD记录号	CSCD:1598008
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/36831
专题	中国科学院心理研究所回溯数据库(1956-2010)
作者单位	中国科学院心理研究所
第一作者单位	中国科学院心理研究所
推荐引用方式 GB/T 7714	Zheng Li,Wang Weiwen,Lin Wenjuan,et al. Expression of c-fos in Amygdala and Conditioned Immunosuppression[J]. Acta Psychologica Sinica,2004,36(4):500-505.
APA	Zheng Li,Wang Weiwen,Lin Wenjuan,Li Jie,&Chen Jihuan.(2004).Expression of c-fos in Amygdala and Conditioned Immunosuppression.Acta Psychologica Sinica,36(4),500-505.
MLA	Zheng Li,et al."Expression of c-fos in Amygdala and Conditioned Immunosuppression".Acta Psychologica Sinica 36.4(2004):500-505.