Sex-specific Association of Antipsychotic-induced Weight Gain and Treatment Response for Antipsychotic-Naive First Episode Schizophrenia Patients: A Prospective 8-week Longitudinal Study

doi:10.1055/a-1353-6544

	Sex-specific Association of Antipsychotic-induced Weight Gain and Treatment Response for Antipsychotic-Naive First Episode Schizophrenia Patients: A Prospective 8-week Longitudinal Study
	Shi, Hui 1; Guan, Xiao Ni 2; Liu, Dian Ying 3; Zhu, Lin 3; Wu, Zhi Wei 4,5; Luo, Guo Zhi 4,5; Wang, Jun2 ; Xiu, Mei Hong 2; Zhang, Xiang Yang 6
通讯作者	Xiu, Mei Hong([email protected]) ; Zhang, Xiang Yang([email protected])
摘要	Background Patients with antipsychotic-naive first-episode (ANFE) schizophrenia (SZ) can help clarify many confounding factors in determining sex differences in antipsychotic drug induced weight gain and its association with symptom improvement. Methods This 8-week longitudinal trial of ANFE patients with SZ enrolled 526 patients and 313 healthy controls. We evaluated bodyweight and the efficacy of antipsychotics on the Positive and Negative Syndrome Scale (PANSS) at baseline and at the end of week 8. Results Males and females after treatment showed no sex difference in weight gain, BMI increase, and percentage of weight gain. However, at baseline, male patients had more positive symptoms than female patients, and decreases in positive symptoms, general psychopathology, and total PANSS scores were less in male than female patients. Adjusting for confounding factors using multiple linear regression confirmed that weight gain was significantly associated with these decreases in PANSS symptoms only in men not women. Conclusions The relationship between weight gain and symptom reduction after 8 weeks of antipsychotic treatment exists only in male patients with ANFE SZ and not in female patients.
关键词	schizophrenia sex difference weight gain therapeutic response body mass index
	2021-03-01
语种	英语
DOI	10.1055/a-1353-6544
发表期刊	PHARMACOPSYCHIATRY
ISSN	0176-3679
卷号	54 期号:02 页码:68-74
收录类别	SCI
资助项目	National Natural Science Foundation of China[81000509]
出版者	GEORG THIEME VERLAG KG
WOS研究方向	Pharmacology & Pharmacy ; Psychiatry
WOS类目	Pharmacology & Pharmacy ; Psychiatry
WOS记录号	WOS:000621184900001
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/38581
专题	中国科学院心理健康重点实验室
通讯作者	Xiu, Mei Hong; Zhang, Xiang Yang
作者单位	1.Capital Med Univ, Beijing Chao Yang Hosp, Dept Clin Psychol, Beijing, Peoples R China 2.Peking Univ, Beijing Hui Long Guan Hosp, Hui Long Guan Clin Med Sch, Beijing, Peoples R China 3.Third Peoples Hosp Ganzhou, Dept Psychiat, Ganzhou, Jiangxi, Peoples R China 4.Shenzhen Kangning Hosp, Dept Psychiat, Shenzhen, Guangdong, Peoples R China 5.Shenzhen Mental Hlth Ctr Shenzhen, Shenzhen, Guangdong, Peoples R China 6.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
通讯作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Shi, Hui,Guan, Xiao Ni,Liu, Dian Ying,et al. Sex-specific Association of Antipsychotic-induced Weight Gain and Treatment Response for Antipsychotic-Naive First Episode Schizophrenia Patients: A Prospective 8-week Longitudinal Study[J]. PHARMACOPSYCHIATRY,2021,54(02):68-74.
APA	Shi, Hui.,Guan, Xiao Ni.,Liu, Dian Ying.,Zhu, Lin.,Wu, Zhi Wei.,...&Zhang, Xiang Yang.(2021).Sex-specific Association of Antipsychotic-induced Weight Gain and Treatment Response for Antipsychotic-Naive First Episode Schizophrenia Patients: A Prospective 8-week Longitudinal Study.PHARMACOPSYCHIATRY,54(02),68-74.
MLA	Shi, Hui,et al."Sex-specific Association of Antipsychotic-induced Weight Gain and Treatment Response for Antipsychotic-Naive First Episode Schizophrenia Patients: A Prospective 8-week Longitudinal Study".PHARMACOPSYCHIATRY 54.02(2021):68-74.