中国科学院心理研究所机构知识库

本文观察了儿茶酚胺的生物合成抑制剂——α-甲基酪氨酸（α-MT）和二乙基二硫氨基甲酸酯钠（DDC）——对群体隔离大白鼠学习和记忆的影响。结果发现α-MT（250mg/公斤体重）对群居动物学习方位水迷津无明显影响,但对隔离动物的学习有明显影响。α-MT对群居和隔离动物的记忆的影响不明显,DDC（500mg/公斤体重）对群居和隔离动物的学习和记忆均无明显影响。注射α-MT后隔离动物大脑皮质内去甲肾上腺素的含量降低了38.1％,而群居动物仅降低了20.1％。结果提示隔离动物对方位水迷津学习能力的降低可能与脑内去甲肾上腺素和多巴胺的含量下降尤其是与大脑皮质内去甲肾上腺素含量的下降有关。 

Effects of inhibition of catecholamines biosynthesis on learning insocially isolated rats were investigated. Both gregarious rats and isolatedrats were divided into α-MT,DDC and control groups, It was foundthat more training was required in the learning of positional watermaze for isolated rats after α-MT injection (250mg/kg, ip), but not sofor gregarious rats. No significant effects of DDC (500mg/kg, ip) on thelearning of positional water maze were observed both in isolated andgregarious rats. A decrease of 38% in cerebral cortex (including hippocampus) con-tents of noradrenaline was observed in isolated rats after α-MT injection,and only a decrease of 20% in gregarious rats. These results suggestthat the decrease of learning ability. in isolated rats is related to thedecrease of brain contents of catecholamines, particularly the contentsof noradrenaline in the cerebral cortex.