Functional connectivity of amygdala subregions predicts vulnerability to depression following the COVID-19 pandemic

doi:https://doi.org/10.1016/j.jad.2021.09.107

	Functional connectivity of amygdala subregions predicts vulnerability to depression following the COVID-19 pandemic
	Zhang, Shudong 1; Cui, Jian 1; Zhang, Zhifang 1; Wang, Yun 1; Liu, Rui1,2 ; Chen, Xiongying 1; Feng, Yuan 1,2; Zhou, Jingjing 1; Zhou, Yuan1,3,4 ; Wang, Gang 1,2
第一作者	Zhang, Shudong
通讯作者	Zhou, Yuan([email protected]) ; Wang, Gang([email protected])
通讯作者邮箱	[email protected]
心理所单位排序	3
摘要	Background The amygdala is vital in processing psychological stress and predicting vulnerability or resilience to stress-related disorders. This study aimed to build the link between functional magnetic resonance imaging data obtained before the stress event and the subsequent stress-related depressive symptoms. Methods Neuroimaging data obtained before the coronavirus disease 2019 pandemic from 39 patients with major depressive disorder (MDD) and 61 health controls (HCs) were used in this study. The participants were divided retrospectively into four groups in accordance with the severity of depressive symptoms during the pandemic: remitted patients, non-remitted patients, depressed HCs (HCd) and non-depressed HCs (HCnd). Seed-based resting-state functional connectivity (rsFC) analyses of the amygdala and its subregions, including the centromedial (CM), the basolateral and the superficial (SF), were performed. Results Vulnerability to depression was suggested by decreased rsFC between the left CM amygdala and the bilateral lingual gyrus in the HCd group compared with the HCnd group, and decreased rsFC of the left CM or right SF amygdala with the precuneus and the postcentral gyrus in the HCd group compared with patients with MDD. No evidence supported the rsFC of the amygdala or its subregions as a biomarker for the resilience of patients with MDD to stress under antidepressant treatment. Limitations Smaller sample size and no longitudinal neuroimaging data. Conclusions Our findings suggested that the rsFC of amygdala subregions may represent a neurobiological marker of vulnerability to depression following stress.
关键词	Amygdala COVID-19 Vulnerability Depression Resting-state functional connectivity
	2021
语种	英语
DOI	https://doi.org/10.1016/j.jad.2021.09.107
发表期刊	Journal of Affective Disorders
ISSN	1573-2517
卷号	297 页码:421-429
期刊论文类型	实证研究
收录类别	SSCI
资助项目	National Key Research & Development Program of China[2016YFC1307200] ; National Natural Science Foundation of China[82071531] ; National Natural Science Foundation of China[81901372] ; National Natural Science Foundation of China[81901368] ; National Natural Science Foundation of China[81771473] ; Capital's Funds for Health Improvement and Research[2020-4-2125] ; Scientific Research Project of Beijing Educational Committee[KM202010025010]
出版者	ELSEVIER
WOS关键词	MENTAL-HEALTH ; STRESS-RESILIENCE ; CHINESE VERSIONS ; QUICK INVENTORY ; ANXIETY ; BRAIN ; SYMPTOMATOLOGY ; NETWORKS ; OUTBREAK ; ANATOMY
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS类目	Clinical Neurology ; Psychiatry
WOS记录号	WOS:000808544900031
资助机构	National Key Research & Development Program of China ; National Natural Science Foundation of China ; Capital's Funds for Health Improvement and Research ; Scientific Research Project of Beijing Educational Committee
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/40642
专题	中国科学院行为科学重点实验室
通讯作者	Zhang, Shudong; Zhou, Yuan
作者单位	1.The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China 2.Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, China 3.CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China 4.Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China
通讯作者单位	中国科学院行为科学重点实验室
推荐引用方式 GB/T 7714	Zhang, Shudong,Cui, Jian,Zhang, Zhifang,et al. Functional connectivity of amygdala subregions predicts vulnerability to depression following the COVID-19 pandemic[J]. Journal of Affective Disorders,2021,297:421-429.
APA	Zhang, Shudong.,Cui, Jian.,Zhang, Zhifang.,Wang, Yun.,Liu, Rui.,...&Wang, Gang.(2021).Functional connectivity of amygdala subregions predicts vulnerability to depression following the COVID-19 pandemic.Journal of Affective Disorders,297,421-429.
MLA	Zhang, Shudong,et al."Functional connectivity of amygdala subregions predicts vulnerability to depression following the COVID-19 pandemic".Journal of Affective Disorders 297(2021):421-429.