| 其他摘要 | Nociceptive stimuli could induce activations in several brain regions, includingthe primary somatosensory cortex, secondary somatosensory cortex, thalamus, insula,and anterior cingulate cortex, as known as “pain matrix”. However, the so-called"pain matrix" might not be specific to pain, as a great part of these brain regions arealso activated in response to stimuli presented through other modalities, suggesting aconsistency across different modalities. To test this possibility, we examined thesimilarity of behavioral performance and brain activities in response to stimulidelivered through different modalities, using both behavioral and neuroimaging datafrom two datasets with 397 healthy subjects in total.
In Study 1, correlation analyses were conducted separately for each dataset onthe subjective ratings of stimulus intensity across modalities (pain, touch, vision, andaudition). As expected, the intensity ratings of stimuli presented from differentmodalities were highly correlated. In addition, the results of principal componentanalysis further indicated that the behavioral ratings had a modality-shared componentand a pain-specific component. The findings demonstrated the modality-sharedcomponent might contribute to the similar brain activation patterns evoked bydifferent modalities and highlighted the possibility to separate the modality-sharedcomponent and the pain-specific component at the behavioral level.
In Study 2, we evaluated brain responses evoked by nociceptive somatosensory,non-nociceptive somatosensory, auditory, and visual stimuli in two datasets, and thenexplored brain activations associated with first two behavioral components extractedin Study 1 using multiple regression analysis. The results showed that themodality-shared component was mainly associated with brain activations in saliencenetwork, including the anterior insula and anterior cingulate cortex, while thepain-specific component was mainly associated with brain activations in the medialdorsal nucleus and insula. These findings suggested that the similar brain activation patterns in different modalities might contribute to the salience of the stimulus.
In Study 3, brain network co-activated in four modalities as wells as activated ineach modality were extracted using constrained principal component analysis. Theresults showed that the co-activated brain networks in four modalities included thesensorimotor network, frontoparietal network, salience network, pain matrix network,default network and visual network. Meanwhile, same brain networks were activatedin each modality, except for somatosensory network. The findings suggested thatdifferent modalities of stimulation could also evoked similar activations of brainnetwork.
In summary, based on the stimulus-induced ratings and functional magneticimaging data from two datasets, this study systematically investigated the sharedmechanisms between nociceptive somatosensory, non-nociceptive somatosensory,auditory, and visual stimulation. This study verified the consistency of ratings andbrain activation patterns among modalities, and shed new insights into the sharedmechanisms from behavioral, brain activation, and brain network perspective. |
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