Identifying subgroups of attention-deficit/hyperactivity disorder from the psychopathological and neuropsychological profiles

doi:10.1111/jnp.12334

	Identifying subgroups of attention-deficit/hyperactivity disorder from the psychopathological and neuropsychological profiles
	Zhang, Shan-hong 1; Yang, Tian-xiao2,3 ; Wu, Zhao-min 1; Wang, Yu-feng 4; Lui, Simon S. Y.5; Yang, Bin-rang 1,6; Chan, Raymond C. K.2,3
通讯作者	Yang, Bin-rang([email protected])
摘要	The Research Domain Criteria (RDoC) advocates the dimensional approach in characterizing mental disorders. We followed RDoC to characterize children with ADHD using profiling based on the cognitive and psychopathological domains. We aimed to identify and validate ADHD subtypes with different clinical characteristics and functional impairments. We recruited 362 drug-naive children with ADHD and 103 typically developing controls. The cluster analysis was used to identify subgroups based on the Child Behaviour Checklist (CBCL) and the Behaviour Rating Inventory of Executive Function (BRIEF). The subgroups' clinical characteristics and functional impairments were assessed using the WEISS Functional Impairment Rating Scale-Parent Report (WFIRS-P) and the Conners Parent Symptom Questionnaire (PSQ). The cluster analysis yielded four subgroups: (1) ADHD with severe impairment in psychopathology and executive functions (EF), (2) ADHD with mild executive dysfunctions and normal-level psychopathology, (3) ADHD with severe externalizing problems and (4) ADHD with severe executive dysfunctions. These subgroups showed different clinical characteristics and degrees of functional impairment. The EF impairment group displayed more serious learning problems and worse life skills than the externalizing group. The two groups with externalizing problems (i.e. the severe impairment group and the externalizing group) both exhibited higher rates of the combined subtype of ADHD and higher rates of comorbid ODD. Different subtypes of ADHD displayed different profiles of internalizing and externalizing problems and levels of executive dysfunctions. In particular, the subtype with severe impairment in EF exhibited more learning problems and worse life skills, suggesting EF is a critical target for intervention in children with ADHD.
关键词	ADHD cluster analysis executive functions externalizing internalizing
	2023-06-28
语种	英语
DOI	10.1111/jnp.12334
发表期刊	JOURNAL OF NEUROPSYCHOLOGY
ISSN	1748-6645
页码	17
收录类别	SCI
资助项目	Sanming Project of Medicine in Shenzhen[SZSM201612036] ; Guangdong High - level Hospital Construction Fund ; National Natural Science Foundation of China[82101613] ; Basic and Applied Basic Research Project of Guangdong Province of China[2019A 1515110700]
出版者	WILEY
WOS关键词	DEFICIT HYPERACTIVITY DISORDER ; LATENT CLASS ANALYSIS ; EXECUTIVE FUNCTION ; SELF-REGULATION ; CHILDREN ; ADHD ; PERFORMANCE ; METAANALYSIS ; CHILDHOOD ; SKILLS
WOS研究方向	Psychology
WOS类目	Psychology ; Psychology, Experimental
WOS记录号	WOS:001018676100001
资助机构	Sanming Project of Medicine in Shenzhen ; Guangdong High - level Hospital Construction Fund ; National Natural Science Foundation of China ; Basic and Applied Basic Research Project of Guangdong Province of China
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/45622
专题	中国科学院心理健康重点实验室
通讯作者	Yang, Bin-rang
作者单位	1.Shenzhen Childrens Hosp, Shenzhen, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Peking Univ Sixth Hosp, Inst Mental Hlth, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China 5.Univ Hong Kong, Sch Clin Med, Dept Psychiat, Hong Kong, Peoples R China 6.Shenzhen Childrens Hosp, 7019 Yitian Rd, Shenzhen 518038, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Shan-hong,Yang, Tian-xiao,Wu, Zhao-min,et al. Identifying subgroups of attention-deficit/hyperactivity disorder from the psychopathological and neuropsychological profiles[J]. JOURNAL OF NEUROPSYCHOLOGY,2023:17.
APA	Zhang, Shan-hong.,Yang, Tian-xiao.,Wu, Zhao-min.,Wang, Yu-feng.,Lui, Simon S. Y..,...&Chan, Raymond C. K..(2023).Identifying subgroups of attention-deficit/hyperactivity disorder from the psychopathological and neuropsychological profiles.JOURNAL OF NEUROPSYCHOLOGY,17.
MLA	Zhang, Shan-hong,et al."Identifying subgroups of attention-deficit/hyperactivity disorder from the psychopathological and neuropsychological profiles".JOURNAL OF NEUROPSYCHOLOGY (2023):17.