Visual Crowding Reveals Field- and Axis-Specific Cortical Miswiring After Long-Term Axial Misalignment in Strabismic Patients Without Amblyopia

doi:10.1167/iovs.64.1.10

	Visual Crowding Reveals Field- and Axis-Specific Cortical Miswiring After Long-Term Axial Misalignment in Strabismic Patients Without Amblyopia
	Huang, Yiru 1; Liu, Zitian 1; Chen, Zidong 1; Zhan, Zongyi 4,5; Gao, Le 1; Hu, Jingyi 1; Wu, Yanyan 1; Yan, Fang-Fang 2,3; Deng, Daming 1; Huang, Chang-Bing2,3,7 ; Yu, Minbin 1,6
通讯作者	Huang, Chang-Bing([email protected]) ; Yu, Minbin([email protected])
摘要	PURPOSE. Inspired by physiological and neuroimaging findings that revealed squint-induced modification of cortical volume and visual receptive field in early visual areas, we hypothesized that strabismic eyes without amblyopia manifest an increase in critical spacing of visual crowding, an essential bottleneck on object recognition and reliable psychophysical index of cortical organization. METHODS. We used real-time eye tracking to ensure gaze-contingent display and examined visual crowding in patients with horizontal concomitant strabismus (both esotropia and exotropia) but without amblyopia and age-matched normal controls. RESULTS. Nineteen patients with exotropia (12 men, mean & PLUSMN; SD = 22.89 & PLUSMN; 7.82 years), 21 patients with esotropia (10 men, mean & PLUSMN; SD = 23.48 & PLUSMN; 6.95 years), and 14 age-matched normal controls (7 men, mean & PLUSMN; SD = 23.07 & PLUSMN; 1.07 years) participated in this study. We found that patients with strabismus without amblyopia showed significantly larger critical spacing with nasotemporal asymmetry in only the radial axis that related to the strabismus pattern, with exotropia exhibiting stronger temporal hemifield crowding and esotropia exhibiting stronger nasal hemifield crowding, in both the deviated and fixating eyes. Moreover, the magnitude of crowding change was related to the duration and degree of strabismic deviation. CONCLUSIONS. Using visual crowding as a psychophysical index of cortical organization, our study demonstrated significantly greater peripheral visual crowding with nasotem-poral asymmetry in only the radial axis in patients with strabismus without amblyopia, indicating the existence of hemifield-and axis-specific miswiring of cortical processing in object recognition induced by long-term adaptation to ocular misalignment.
关键词	visual crowding strabismus long-term axial misalignment cortical miswiring
	2023
语种	英语
DOI	10.1167/iovs.64.1.10
发表期刊	INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
ISSN	0146-0404
卷号	64 期号:1 页码:11
收录类别	SCI
资助项目	Natural Science Foundation Team Project of Guangdong Province Grant[2015A030312016] ; Guangdong Basic and Applied Basic Research Foundation[2021A1515110479] ; Natural Science Foundation of China[NSFC 32100864] ; Natural Science Foundation of China[NSFC 32071056]
出版者	ASSOC RESEARCH VISION OPHTHALMOLOGY INC
WOS关键词	OBJECT RECOGNITION ; OCULAR DOMINANCE ; PERCEPTION ; VISION ; ACUITY ; RESOLUTION ; CORTEX ; SHAPE ; EYE
WOS研究方向	Ophthalmology
WOS类目	Ophthalmology
WOS记录号	WOS:001043015700005
资助机构	Natural Science Foundation Team Project of Guangdong Province Grant ; Guangdong Basic and Applied Basic Research Foundation ; Natural Science Foundation of China
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/45906
专题	中国科学院行为科学重点实验室
通讯作者	Huang, Chang-Bing; Yu, Minbin
作者单位	1.Sun Yat sen Univ, Zhongshan Ophthalm Ctr, Guangdong Prov Clin Res Ctr Ocular Dis, State Key Lab Ophthalmol,Guangdong Prov Key Lab Op, Guangzhou, Guangdong, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Jinan Univ, Shenzhen Eye Hosp, Shenzhen Eye Inst, Shenzhen, Peoples R China 5.Shenzhen Univ, Sch Optometry, Shenzhen, Peoples R China 6.Sun Yat sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangdong Prov Key Lab Ophthalmol & Visual Sci, Guangzhou, Guangdong, Peoples R China 7.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
通讯作者单位	中国科学院行为科学重点实验室; 中国科学院心理研究所
推荐引用方式 GB/T 7714	Huang, Yiru,Liu, Zitian,Chen, Zidong,et al. Visual Crowding Reveals Field- and Axis-Specific Cortical Miswiring After Long-Term Axial Misalignment in Strabismic Patients Without Amblyopia[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,2023,64(1):11.
APA	Huang, Yiru.,Liu, Zitian.,Chen, Zidong.,Zhan, Zongyi.,Gao, Le.,...&Yu, Minbin.(2023).Visual Crowding Reveals Field- and Axis-Specific Cortical Miswiring After Long-Term Axial Misalignment in Strabismic Patients Without Amblyopia.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,64(1),11.
MLA	Huang, Yiru,et al."Visual Crowding Reveals Field- and Axis-Specific Cortical Miswiring After Long-Term Axial Misalignment in Strabismic Patients Without Amblyopia".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 64.1(2023):11.