中国科学院行为科学重点实验室知识库

目的:比较静息状态下单相抑郁障碍（unipolar depression，UD）、双相抑郁障碍（bipolar depression，BD）患者执行控制网络（executive control network，ECN）、突显网络（salience network，SN）和默认网络（default mode network，DMN）网络内及网络间效应连接的异同，并分析UD与BD患者之间效应连接差异与临床症状的相关性。方法:于2021年3月至2022年6月纳入18~35岁未服药的39例UD患者（UD组）、24例BD患者（BD组）和50例健康对照者（healthy control，HC；HC组），采集所有受试者的静息态功能磁共振成像（functional magnetic resonance imaging，fMRI）和T 1结构像数据。采用基于频谱的动态因果模型分析方法，检测3组ECN、SN和DMN网络内及网络间效应连接的差异，并进一步采用典型相关的分析方法检测2个患者组之间效应连接的差异与临床症状的相关性。 结果:与HC组相比，2个患者组均表现出SN网络的网络内兴奋性效应降低［效应连接值均为-0.04，后验概率（posterior probability， Pp）=1.00］，且UD组降低更明显（效应连接值=0.02， Pp=0.97）。2个患者组比较显示差异的效应连接较广泛。进一步的相关分析发现，BD组较UD组降低的效应连接与BD组患者的抑郁（χ 2=1 696.10， P<0.01）和躁狂（χ 2=1 699.30， P<0.01）症状均相关，与UD组抑郁症状（χ 2=1 696.10， P<0.01）相关。 结论:UD和BD患者存在共同的和差异性的核心脑网络效应连接特征，且差异性的特征均与患者抑郁症状的严重程度相关。

Abstract：Objective:To compare the similarity and differences in the intra-and inter-network connectivity effects of the Executive Control Network (ECN), Salience Network (SN) and Default Mode Network (DMN) in patients with unipolar depression (UD) and bipolar depression (BD) patients at resting state. Additionally, the study aims to explore the correlations between clinical symptoms and connectivity differences in the two types of patients.Methods:From March 2021 to June 2022, resting-state functional magnetic resonance imaging (fMRI) and T 1 structural imaging data were collected from 39 UD patients, 24 BD patients and 50 healthy controls (HC) who were between 18-35 years of age, without being treated by medications. Spectral dynamic causal modeling (spDCM) analysis investigated differences in intra-and inter-network connectivity effects between the two patient groups. Furthermore, the canonical correlation analysis method was used to detect correlations between clinical symptoms and connectivity differences. Results:Compared to the HC, both of UD and BD groups showed decreased excitatory effect within the SN (effective connectivity value=-0.04, posterior probability( Pp)=1.00), with the UD group showing a more pronounced reduction (effective connectivity value=0.02, Pp=0.97). The differences in connectivity effects between the two patient groups were extensive. Further correlation analyses found that the decreased connectivity effects in the BD, compared to the UD group, were associated with depressive (χ 2=1 696.10, P<0.01) and manic symptoms (χ 2=1 699.30, P<0.01)symptoms in the BD group, as well as depressive symptoms in the UD group (χ 2=1 696.10, P<0.01). Conclusions:UD and BD patients exhibit shared and distinct core brain connectivity characteristics, and the differing features correlate with the severity of depressive symptoms in both UD and BD patients.