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Shared atypical spontaneous brain activity pattern in early onset schizophrenia and autism spectrum disorders: evidence from cortical surface-based analysis
Jin, Xingyue1,2; Zhang, Kun1,2; Lu, Bin3,7; Li, Xue4; Yan, Chao-Gan3,7; Du, Yasong5; Liu, Yi5; Lu, Jianping6; Luo, Xuerong1,2; Gao, Xueping1,2; Liu, Jing4
第一作者Xingyue Jin
通讯作者邮箱luoxuerong@ csu.edu.cn (xuerong luo) ; [email protected] (xueping gao) ; [email protected] (jing liu)
心理所单位排序4
摘要

Schizophrenia and autism spectrum disorders (ASD) were considered as two neurodevelopmental disorders and had shared clinical features. we hypothesized that they have some common atypical brain functions and the purpose of this study was to explored the shared brain spontaneous activity strength alterations in early onset schizophrenia (EOS) and ASD in the children and adolescents with a multi-center large-sample study. A total of 171 EOS patients (aged 14.25 +/- 1.87), 188 ASD patients (aged 9.52 +/- 5.13), and 107 healthy controls (aged 11.52 +/- 2.82) had scanned with Resting-fMRI and analyzed surface-based amplitude of low-frequency fluctuations (ALFF). Results showed that both EOS and ASD had hypoactivity in the primary sensorimotor regions (bilateral primary and early visual cortex, left ventral visual stream, left primary auditory cortex) and hyperactivity in the high-order transmodal regions (bilateral SFL, bilateral DLPFC, right frontal eye fields), and bilateral thalamus. EOS had more severe abnormality than ASD. This study revealed shared functional abnormalities in the primary sensorimotor regions and the high-order transmodal regions in EOS and ASD, which provided neuroimaging evidence of common changes in EOS and ASD, and may help with better early recognition and precise treatment for EOS and ASD.

关键词Schizophrenia EOS ASD Autism fMRI ALFF Cortex
2023-12-26
语种英语
DOI10.1007/s00787-023-02333-2
发表期刊EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
ISSN1018-8827
页码10
期刊论文类型实证研究
收录类别SCI ; SSCI
资助项目National Key R&D Program of China
出版者SPRINGER
WOS关键词AUDITORY VERBAL HALLUCINATIONS ; DEFAULT-MODE NETWORK ; FUNCTIONAL CONNECTIVITY ; DEFICITS ; CORTEX ; ABNORMALITIES ; LOCALIZATION ; OSCILLATIONS ; ORGANIZATION ; METAANALYSIS
WOS研究方向Psychology ; Pediatrics ; Psychiatry
WOS类目Psychology, Developmental ; Pediatrics ; Psychiatry
WOS记录号WOS:001135764100004
WOS分区Q1
资助机构National Key R&D Program of China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/46826
专题中国科学院行为科学重点实验室
通讯作者Luo, Xuerong; Gao, Xueping; Liu, Jing
作者单位1.Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Dept Psychiat, Changsha 410011, Hunan, Peoples R China
2.Cent South Univ, Xiangya Hosp 2, Natl Ctr Mental Disorders, Changsha 410011, Hunan, Peoples R China
3.Peking Univ, Natl Clin Res Ctr Mental Disorders, Hosp 6, NHC Key Lab Mental Hlth, 51 Huayuan Rd, Beijing 100191, Peoples R China
4.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
5.Shanghai Mental Hlth Ctr, 600 Wanping Nan Rd, Shanghai 200030, Peoples R China
6.Shenzhen Kangning Hosp, Shenzhen Mental Hlth Ctr, Dept Child Psychiat, Shenzhen, Peoples R China
7.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
通讯作者单位中国科学院行为科学重点实验室
推荐引用方式
GB/T 7714
Jin, Xingyue,Zhang, Kun,Lu, Bin,et al. Shared atypical spontaneous brain activity pattern in early onset schizophrenia and autism spectrum disorders: evidence from cortical surface-based analysis[J]. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY,2023:10.
APA Jin, Xingyue.,Zhang, Kun.,Lu, Bin.,Li, Xue.,Yan, Chao-Gan.,...&Liu, Jing.(2023).Shared atypical spontaneous brain activity pattern in early onset schizophrenia and autism spectrum disorders: evidence from cortical surface-based analysis.EUROPEAN CHILD & ADOLESCENT PSYCHIATRY,10.
MLA Jin, Xingyue,et al."Shared atypical spontaneous brain activity pattern in early onset schizophrenia and autism spectrum disorders: evidence from cortical surface-based analysis".EUROPEAN CHILD & ADOLESCENT PSYCHIATRY (2023):10.
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