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Shared atypical spontaneous brain activity pattern in early onset schizophrenia and autism spectrum disorders: evidence from cortical surface-based analysis | |
Jin, Xingyue1,2; Zhang, Kun1,2; Lu, Bin3,7; Li, Xue4; Yan, Chao-Gan3,7; Du, Yasong5; Liu, Yi5; Lu, Jianping6; Luo, Xuerong1,2; Gao, Xueping1,2; Liu, Jing4 | |
第一作者 | Xingyue Jin |
通讯作者邮箱 | luoxuerong@ csu.edu.cn (xuerong luo) ; [email protected] (xueping gao) ; [email protected] (jing liu) |
心理所单位排序 | 4 |
摘要 | Schizophrenia and autism spectrum disorders (ASD) were considered as two neurodevelopmental disorders and had shared clinical features. we hypothesized that they have some common atypical brain functions and the purpose of this study was to explored the shared brain spontaneous activity strength alterations in early onset schizophrenia (EOS) and ASD in the children and adolescents with a multi-center large-sample study. A total of 171 EOS patients (aged 14.25 +/- 1.87), 188 ASD patients (aged 9.52 +/- 5.13), and 107 healthy controls (aged 11.52 +/- 2.82) had scanned with Resting-fMRI and analyzed surface-based amplitude of low-frequency fluctuations (ALFF). Results showed that both EOS and ASD had hypoactivity in the primary sensorimotor regions (bilateral primary and early visual cortex, left ventral visual stream, left primary auditory cortex) and hyperactivity in the high-order transmodal regions (bilateral SFL, bilateral DLPFC, right frontal eye fields), and bilateral thalamus. EOS had more severe abnormality than ASD. This study revealed shared functional abnormalities in the primary sensorimotor regions and the high-order transmodal regions in EOS and ASD, which provided neuroimaging evidence of common changes in EOS and ASD, and may help with better early recognition and precise treatment for EOS and ASD. |
关键词 | Schizophrenia EOS ASD Autism fMRI ALFF Cortex |
2023-12-26 | |
语种 | 英语 |
DOI | 10.1007/s00787-023-02333-2 |
发表期刊 | EUROPEAN CHILD & ADOLESCENT PSYCHIATRY |
ISSN | 1018-8827 |
页码 | 10 |
期刊论文类型 | 实证研究 |
收录类别 | SCI ; SSCI |
资助项目 | National Key R&D Program of China |
出版者 | SPRINGER |
WOS关键词 | AUDITORY VERBAL HALLUCINATIONS ; DEFAULT-MODE NETWORK ; FUNCTIONAL CONNECTIVITY ; DEFICITS ; CORTEX ; ABNORMALITIES ; LOCALIZATION ; OSCILLATIONS ; ORGANIZATION ; METAANALYSIS |
WOS研究方向 | Psychology ; Pediatrics ; Psychiatry |
WOS类目 | Psychology, Developmental ; Pediatrics ; Psychiatry |
WOS记录号 | WOS:001135764100004 |
WOS分区 | Q1 |
资助机构 | National Key R&D Program of China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/46826 |
专题 | 中国科学院行为科学重点实验室 |
通讯作者 | Luo, Xuerong; Gao, Xueping; Liu, Jing |
作者单位 | 1.Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Dept Psychiat, Changsha 410011, Hunan, Peoples R China 2.Cent South Univ, Xiangya Hosp 2, Natl Ctr Mental Disorders, Changsha 410011, Hunan, Peoples R China 3.Peking Univ, Natl Clin Res Ctr Mental Disorders, Hosp 6, NHC Key Lab Mental Hlth, 51 Huayuan Rd, Beijing 100191, Peoples R China 4.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China 5.Shanghai Mental Hlth Ctr, 600 Wanping Nan Rd, Shanghai 200030, Peoples R China 6.Shenzhen Kangning Hosp, Shenzhen Mental Hlth Ctr, Dept Child Psychiat, Shenzhen, Peoples R China 7.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
通讯作者单位 | 中国科学院行为科学重点实验室 |
推荐引用方式 GB/T 7714 | Jin, Xingyue,Zhang, Kun,Lu, Bin,et al. Shared atypical spontaneous brain activity pattern in early onset schizophrenia and autism spectrum disorders: evidence from cortical surface-based analysis[J]. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY,2023:10. |
APA | Jin, Xingyue.,Zhang, Kun.,Lu, Bin.,Li, Xue.,Yan, Chao-Gan.,...&Liu, Jing.(2023).Shared atypical spontaneous brain activity pattern in early onset schizophrenia and autism spectrum disorders: evidence from cortical surface-based analysis.EUROPEAN CHILD & ADOLESCENT PSYCHIATRY,10. |
MLA | Jin, Xingyue,et al."Shared atypical spontaneous brain activity pattern in early onset schizophrenia and autism spectrum disorders: evidence from cortical surface-based analysis".EUROPEAN CHILD & ADOLESCENT PSYCHIATRY (2023):10. |
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