Substantial Heritability Underlies Fairness Norm Adaptation Capability and its Neural Basis

doi:10.1002/advs.202411070

PSYCH OpenIR

	Substantial Heritability Underlies Fairness Norm Adaptation Capability and its Neural Basis
	Jin, Yuening 1,2; Zheng, Dang 1,3; Gu, Ruolei 1,2; Fan, Qingchen 1,2; Dietz, Martin 4; Wang, Changshuo 1,5,6; Li, Xinying 2,7; Chen, Jie 2,7; Hu, Yuanyuan 1,2; Zhou, Yuan 1,2,8,9
通讯作者	Zhou, Yuan([email protected])
摘要	The present research uncovers the shared genetic underpinnings of fairness norm adaptation capability, its neural correlates, and long-term mental health outcomes. One hundred and eighty-six twins are recruited and played as responders in the Ultimatum Game (UG) while undergoing fMRI scanning in their early adulthood (Study-1) and are measured on depressive symptoms eight years later (Study-2). With computational modeling, the process of norm adaptation is differentiated from that of fairness valuation in UG. The two processes both have moderate levels of heritability. The anterior insula has a significant phenotypic correlation, whereas the Supplementary Motor Area/Medial Frontal Gyrus (SMA/mSFG) shows both a significant phenotypic correlation and a shared genetic influence with the learning rate, an index for norm adaptation. The dopaminergic DRD2 polymorphisms correlate with both the learning rate and the SMA/mSFG encoding of prediction error, constituting of their common genetic basis. Regional gene expression analysis reveals the high expression of dopamine-related genes in the SMA/mSFG. Moreover, the learning rate can predict depressive symptom severity eight years later, with the DRD2 polymorphisms constituting their shared genetic basis. This suggests that heritability is a non-negligible driving force behind norm adaptation, which facilitates the learning of social norms in changing environments and preserves long-term mental health.
关键词	anterior insula fairness norm adaptation genetics prediction error encoding supplementary motor area twin studies
	2024-12-16
语种	英语
DOI	10.1002/advs.202411070
发表期刊	ADVANCED SCIENCE
页码	18
收录类别	SCI
资助项目	STI2030-Major Projects[2021ZD0200600] ; Institute of Psychology, Chinese Academy of Sciences[82171535] ; Institute of Psychology, Chinese Academy of Sciences[72033006] ; Institute of Psychology, Chinese Academy of Sciences[81771473] ; Institute of Psychology, Chinese Academy of Sciences[32130045] ; Institute of Psychology, Chinese Academy of Sciences[91432302] ; National Natural Science Foundation of China[E2CX3815CX] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences
出版者	WILEY
WOS关键词	ULTIMATUM GAME ; RECEPTOR GENE ; SEROTONIN ; DOPAMINE ; BRAIN ; ENVIRONMENT ; VIOLATIONS ; SYMPTOMS ; ROLES
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:001378046800001
资助机构	STI2030-Major Projects ; Institute of Psychology, Chinese Academy of Sciences ; National Natural Science Foundation of China ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/47282
通讯作者	Zhou, Yuan
作者单位	1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 3.China Natl Childrens Ctr, Dept Early Childhood Educ, Beijing 100035, Peoples R China 4.Aarhus Univ, Inst Clin Med, Ctr Functionally Integrat Neurosci, Univ Byen 3, DK-8000 Aarhus, Denmark 5.Univ Chinese Acad Sci, Sino Danish Ctr, Beijing 100049, Peoples R China 6.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 7.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 8.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China 9.Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Jin, Yuening,Zheng, Dang,Gu, Ruolei,et al. Substantial Heritability Underlies Fairness Norm Adaptation Capability and its Neural Basis[J]. ADVANCED SCIENCE,2024:18.
APA	Jin, Yuening.,Zheng, Dang.,Gu, Ruolei.,Fan, Qingchen.,Dietz, Martin.,...&Zhou, Yuan.(2024).Substantial Heritability Underlies Fairness Norm Adaptation Capability and its Neural Basis.ADVANCED SCIENCE,18.
MLA	Jin, Yuening,et al."Substantial Heritability Underlies Fairness Norm Adaptation Capability and its Neural Basis".ADVANCED SCIENCE (2024):18.