Early-treatment cerebral blood flow change as a predictive biomarker of antidepressant treatment response: evidence from the EMBARC clinical trial

doi:10.1017/S0033291724001156

	Early-treatment cerebral blood flow change as a predictive biomarker of antidepressant treatment response: evidence from the EMBARC clinical trial
	Dang, Yi 1; Lu, Bin2,3,4 ; Vanderwal, Tamara 5,6; Castellanos, Francisco Xavier 7,8; Yan, Chao-Gan1,2,3,4
通讯作者	Yan, Chao-Gan([email protected])
摘要	Background Major depressive disorder (MDD) is one of the most prevalent and disabling illnesses worldwide. Treatment of MDD typically relies on trial-and-error to find an effective approach. Identifying early response-related biomarkers that predict response to antidepressants would help clinicians to decide, as early as possible, whether a particular treatment might be suitable for a given patient.Methods Data were from the two-stage Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC) trial. A whole-brain, voxel-wise, mixed-effects model was applied to identify early-treatment cerebral blood flow (CBF) changes as biomarkers of treatment response. We examined changes in CBF measured with arterial spin labeling 1-week after initiating double-masked sertraline/placebo. We tested whether these early 1-week scans could be used to predict response observed after 8-weeks of treatment.Results Response to 8-week placebo treatment was associated with increased cerebral perfusion in temporal cortex and reduced cerebral perfusion in postcentral region captured at 1-week of treatment. Additionally, CBF response in these brain regions was significantly correlated with improvement in Hamilton Depression Rating Scale score in the placebo group. No significant associations were found for selective serotonin reuptake inhibitor treatment.Conclusions We conclude that early CBF responses to placebo administration in multiple brain regions represent candidate neural biomarkers of longer-term antidepressant effects.
关键词	antidepressant arterial spin labeling biomarker cerebral blood flow EMBARC
	2024-05-09
语种	英语
DOI	10.1017/S0033291724001156
发表期刊	PSYCHOLOGICAL MEDICINE
ISSN	0033-2917
页码	10
收录类别	SCI
资助项目	Technical Support Talents Project of Chinese Academy of Sciences[E2CX1154] ; Sci-Tech Innovation 2030-Major Project of Brain Science and Brain-inspired Intelligence Technology[2021ZD0200600] ; National Natural Science Foundation of China[82122035] ; National Natural Science Foundation of China[81671774] ; National Natural Science Foundation of China[81630031] ; The 13th Five-year Informatization Plan of Chinese Academy of Sciences[XXH13505] ; Key Research Program of the Chinese Academy of Sciences[ZDBS-SSW-JSC006] ; Beijing Nova Program of Science and Technology[Z191100001119104] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E2CX4425YZ] ; NIMH[U01MH092221] ; NIMH[U01MH092250]
出版者	CAMBRIDGE UNIV PRESS
WOS关键词	MAJOR DEPRESSIVE DISORDER ; SPIN-LABELING MRI ; GRAY-MATTER ; BRAIN ; CONNECTIVITY ; PLACEBO ; CORTEX ; METAANALYSIS ; STATE
WOS研究方向	Psychology ; Psychiatry
WOS类目	Psychology, Clinical ; Psychiatry ; Psychology
WOS记录号	WOS:001215859000001
资助机构	Technical Support Talents Project of Chinese Academy of Sciences ; Sci-Tech Innovation 2030-Major Project of Brain Science and Brain-inspired Intelligence Technology ; National Natural Science Foundation of China ; The 13th Five-year Informatization Plan of Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; Beijing Nova Program of Science and Technology ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; NIMH
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/47661
专题	中国科学院行为科学重点实验室
通讯作者	Yan, Chao-Gan
作者单位	1.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Int Big Data Ctr Depress Res, Beijing, Peoples R China 5.Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada 6.BC Childrens Hosp Res Inst, Vancouver, BC, Canada 7.NYU Robert I Grossman Sch Med, Dept Child & Adolescent Psychiat, New York, NY USA 8.Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA
第一作者单位	管理支撑系统
通讯作者单位	管理支撑系统; 中国科学院行为科学重点实验室
推荐引用方式 GB/T 7714	Dang, Yi,Lu, Bin,Vanderwal, Tamara,et al. Early-treatment cerebral blood flow change as a predictive biomarker of antidepressant treatment response: evidence from the EMBARC clinical trial[J]. PSYCHOLOGICAL MEDICINE,2024:10.
APA	Dang, Yi,Lu, Bin,Vanderwal, Tamara,Castellanos, Francisco Xavier,&Yan, Chao-Gan.(2024).Early-treatment cerebral blood flow change as a predictive biomarker of antidepressant treatment response: evidence from the EMBARC clinical trial.PSYCHOLOGICAL MEDICINE,10.
MLA	Dang, Yi,et al."Early-treatment cerebral blood flow change as a predictive biomarker of antidepressant treatment response: evidence from the EMBARC clinical trial".PSYCHOLOGICAL MEDICINE (2024):10.